FlyBase Allele Report: Dmel\apt[MT287]

General Information

Symbol

Dmel\apt^MT287

Species

D. melanogaster

Name

FlyBase ID

FBal0180960

Feature type

allele

Associated gene

Dmel\apt

Associated Insertion(s)

P{5'KZ.TRAP.MT287}apt^MT287

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Takasu-Ishikawa et al., 2001)

Mutagen

Delta2-3 transposase

(Takasu-Ishikawa et al., 2001)

Progenitor genotype

apt^MY7919

(Takasu-Ishikawa et al., 2001)

Associated Insertion(s)

P{5'KZ.TRAP.MT287}apt^MT287

Cytology

Description

Imprecise excision of the P{KZ.TRAP} insertion in apt^MY7919. This leaves behind the T:Khc and Ecol\lacZ region of the P{KZ.TRAP} element and leads to deletion of the whole first exon of apt.

(Takasu-Ishikawa et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | embryonic stage

(Takasu-Ishikawa et al., 2001)

lethal - all die during embryonic stage | recessive

(Takasu-Ishikawa et al., 2001)

some die during embryonic stage | recessive

(Takasu-Ishikawa et al., 2001)

Phenotype Manifest In

embryo | dorsal closure stage

(Takasu-Ishikawa et al., 2001)

embryonic head

(Takasu-Ishikawa et al., 2001)

larval ventral nerve cord

(Takasu-Ishikawa et al., 2001)

neuromuscular junction

(Takasu-Ishikawa et al., 2001)

Detailed Description

Statement

Reference

Most apt^MT287 homozygous mutants are unable to hatch. Homozygous apt^MT287 embryos do not exhibit ventral nerve cord shortening, as usually occurs during stage 17. Additionally, apt^MT287 homozygous embryos have a defect in head involution. Homozygous apt^MT287 mutants have no coordinated muscle contraction. The mutants have electrophysiological defects; synaptic activities are the same in apt^MT287 mutants as in apt^MY7919 mutants. Some apt^MT287 embryos have neuromuscular junctions that are less well-developed than wild-type embryos of the same age. Varicosities in these mutants appear smaller and embedded in the muscle fibre. Postsynaptic specializations are small in diameter, and presynaptic densities are rare and not well formed.

(Takasu-Ishikawa et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

apt^FS1

(Takasu-Ishikawa et al., 2001)

apt^FS2

(Takasu-Ishikawa et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

apt^MT287

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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