FB2026_03 , released September 17, 2026
Allele: Dmel\Top3α191
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General Information
Symbol
Dmel\Top3α191
Species
D. melanogaster
Name
FlyBase ID
FBal0181193
Feature type
allele
Associated gene
Dmel\Top3α
Associated Insertion(s)
P{EP-Δ191}Top3α191
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Plank et al., 2005)
Progenitor genotype
Top3αEP2272
(Plank et al., 2005)
Associated Insertion(s)
P{EP-Δ191}Top3α191
Cytology
Description

Imprecise excision of the P{EP} element, resulting in a large internal deletion of the element (which removes the w+mC marker.

(Plank et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae pupate on average 9.8 days after hatching, compared to an average of 8.2 days for control larvae. After pupation, the homozygotes develop melanotic bodies, probably due to necrotic tissue and they never eclose. A significant proportion of homozygous embryos are also lost. Some late third instar larvae also have melanotic bodies.

      (Plank et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Top3α191 has lethal | recessive phenotype, non-suppressible by Top3βhs.PP

      (Plank et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Top3α191 is partially rescued by Top3αhs.PP

      (Plank et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Top3α191
      Name Synonyms
      Secondary FlyBase IDs
        References (1)