FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SppRNAi.UAS
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General Information
Symbol
Dmel\SppRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0181465
Feature type
allele
Associated gene
Dmel\Spp
Associated Insertion(s)
Carried in Construct
P{UAS-Spp.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Casso et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Casso et al., 2005)
Mutagen
in vitro construct
(Casso et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Spp.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of a repeat in tail-to-tail orientation of a 1167bp fragment comprising the entire Spp coding region minus the initiating methionine codon. The construct is designed to produce dsRNA.

(Casso et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Spp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Miller et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Co-expression of SppdsRNA.Scer\UAS suppresses the wing notching caused by expression of SppScer\UAS.cCa under the control of Scer\GAL4en-e16E.

      (Casso et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used to study the phenotypic consequences of dsRNA interference (RNAi) of the Spp gene.

      (Casso et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SppRNAi.UAS
      SppdsRNA.Scer\UAS
      SppdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)