FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sirt4white+1
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General Information
Symbol
Dmel\Sirt4white+1
Species
D. melanogaster
Name
FlyBase ID
FBal0181529
Feature type
allele
Associated gene
Dmel\Sirt4
Associated Insertion(s)
TI{TI}Sirt4white+1
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Xie and Golic, 2005.6.1)
Mutagen
recombination
(Xie and Golic, 2005.6.1)
ends-out gene targeting
(Xie and Golic, 2005.6.1)
Progenitor genotype
Associated Insertion(s)
TI{TI}Sirt4white+1
Cytology
Description

Deletion of the Sirt4 coding region. A mini-w marker introduced during the mutagenic event is also present.

(Xie and Golic, 2005.6.1)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sirt4white+1 are short lived in a range of dietary conditions and adults show a progressive decrease in climbing ability, as compared to controls.

      (Parik et al., 2018)

      Sirt4white+1 flies show significantly decreased lifespan and locomotor activity under high calorie diet, low calorie or starvation, while maintaining normal circadian periodicity, as compared to wild-type controls. Despite this, Sirt4white+1 flies still show the expected increases in lifespan and spontaneous activity, and decrease in female fecundity upon calorie restriction normally observed in wild-type controls.

      (Wood et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sirt4white+1
      (Wood et al., 2018)
      dSirt4 KO
      (Wood et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)