FlyBase Allele Report: Dmel\RpL38[2b2]

General Information

Symbol

Dmel\RpL38^2b2

Species

D. melanogaster

Name

FlyBase ID

FBal0181802

Feature type

allele

Associated gene

Dmel\RpL38

Associated Insertion(s)

Carried in Construct

Also Known As

E-2b²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Coelho et al., 2005, Marygold et al., 2005)

Progenitor genotype

Cytology

Description

Point mutation in the splice acceptor site of the single intron immediately before the initiating ATG.

(Marygold et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:4,516,320..4,516,320 [-]

Nucleotide change:

G4516320A

Reported nucleotide change:

G?A

Comment:

Point mutation in the splice acceptor site immediately before the initiating ATG.

(Marygold et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | dominant

(Marygold et al., 2005)

decreased cell number | dominant

(Marygold et al., 2005)

increased cell size | dominant

(Marygold et al., 2005)

lethal (with RpL38^NC21)

(Marygold et al., 2005)

lethal | embryonic stage (with RpL38^2b1)

(Coelho et al., 2005)

lethal | larval stage (with RpL38^2b1)

(Coelho et al., 2005)

lethal - all die during embryonic stage (with RpL38^2b1)

(Marygold et al., 2005)

Minute

(Marygold et al., 2007)

Minute (with RpL38^NC21)

(Marygold et al., 2005)

Minute | dominant

(Coelho et al., 2005, Marygold et al., 2005)

some die during embryonic stage (with RpL38^2b1)

(Marygold et al., 2005)

visible (with RpL38^NC21)

(Marygold et al., 2005)

Phenotype Manifest In

chaeta

(Coelho et al., 2005, Marygold et al., 2005)

chaeta (with RpL38^NC21)

(Marygold et al., 2005)

wing (with RpL38^NC21)

(Marygold et al., 2005)

wing vein | ectopic (with RpL38^NC21)

(Marygold et al., 2005)

Detailed Description

Statement

Reference

Heterozygotes have a Minute bristle phenotype. RpL38^2b1/RpL38^2b2 animals die either as embryos or soon after hatching.

(Coelho et al., 2005)

Heterozygous adults have short, slender bristles and eclose with a delay of about a day compared to control flies. Heterozygous adults show an increase in cell size and a decrease in cell number in the wing, which overall results in an increase in total wing area compared to controls. RpL38^2b2/RpL38^NC21 animals show 6% viability and have a strong Minute small-bristle phenotype. These animals also show extra venation on the wing.

(Marygold et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b2 is an enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

RpL38[+]/RpL38^2b2 is an enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b2 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

RpL38[+]/RpL38^2b2 is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

NOT Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b2 is a non-enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

RpL38^2b2 dominantly enhances the small wing phenotype caused by expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096, but does not enhance the argos^Scer\UAS.cMa ; Scer\GAL4^Bx-MS1096 wing vein loss phenotype.

(Coelho et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25913

w^*; RpL38^2b2/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

Notes on Origin

Discoverer

Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096.

(Coelho et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E-2b²

(Coelho et al., 2005, Marygold et al., 2005)

RpL38^2b2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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