FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RhoGEF2PX6
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General Information
Symbol
Dmel\RhoGEF2PX6
Species
D. melanogaster
Name
FlyBase ID
FBal0181885
Feature type
allele
Associated gene
Dmel\RhoGEF2
Associated Insertion(s)
P{?PZ}RhoGEF2PX6
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Nikolaidou, 2004, Nikolaidou and Barrett, 2004)
Mutagen
P-element activity
(Nikolaidou, 2004)
Progenitor genotype
P{PZ}RhoGEF204291
(Nikolaidou, 2004)
Associated Insertion(s)
P{?PZ}RhoGEF2PX6
Cytology
Description

Imprecise excision of the P{PZ} insertion. A 2132bp insertion remains in intron 1.

(Nikolaidou, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RhoGEF2PX6/RhoGEF24.1 animals show 27% adult viability. 70% of the adults have wing defects; wings are crumpled and/or blistered. Wing discs of mid-third-instar larvae appear buckled, rather than having the normal pattern of folding.

      (Nikolaidou and Barrett, 2004)

      The planar polarity of hairs in RhoGEF24.1/RhoGEF2PX6 clones in the wing is normal.

      (Nikolaidou, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      RhoGEF2PX6/RhoGEF24.1 has visible phenotype, enhanceable by cta5/cta[+]

      (Nikolaidou and Barrett, 2004)

      RhoGEF2PX6/RhoGEF24.1 has partially lethal phenotype, enhanceable by cta5/cta[+]

      (Nikolaidou and Barrett, 2004)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      RhoGEF2PX6/RhoGEF24.1 has wing phenotype, enhanceable by cta5/cta[+]

      (Nikolaidou and Barrett, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      RhoGEF2PX6/cta5 RhoGEF24.1 animals show 8% adult viability. The frequency of wing defects in these animals is 92% (compared to 70% in RhoGEF2PX6/RhoGEF24.1 adults).

      (Nikolaidou and Barrett, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DRhoGEF2PX6
      (Nikolaidou and Barrett, 2004)
      PX6
      (Nikolaidou, 2004)
      RhoGEF2PX6
      (Corrigall et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)