FB2026_02 , released June 18, 2026
Allele: Dmel\Pak3LA00012
Open Close
General Information
Symbol
Dmel\Pak3LA00012
Species
D. melanogaster
Name
FlyBase ID
FBal0182356
Feature type
allele
Associated gene
Dmel\Pak3
Associated Insertion(s)
P{Mae-UAS.6.11}Pak3LA00012
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Merriam, 2005.11.18)
Progenitor genotype
Associated Insertion(s)
P{Mae-UAS.6.11}Pak3LA00012
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{Mae-UAS.6.11}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  hereditary spastic paraplegia 4
      modeled by spasT32
      (Ozdowski et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuronal expression of Pak3LA00012 under the control of Scer\GAL4elav.PU reduces microtubules in terminal synaptic boutons. The amount of branching at the NMJ is also significantly increased, and these branches resemble filopodial projections. These projections are seen in type Is and 1b glutamatergic neurons.

      (Ozdowski et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Pak3LA00012, Scer\GAL4GMR.PU is an enhancer of visible phenotype of Scer\GAL4GMR.PU, spasT32

      (Ozdowski et al., 2011)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Pak3LA00012, Scer\GAL4GMR.PU is an enhancer of eye phenotype of Scer\GAL4GMR.PU, spasT32

      (Ozdowski et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Pak3LA00012 enhances the eye phenotype seen when spasT32 is expressed under the control of Scer\GAL4GMR.PU.

      (Ozdowski et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The insertion of P{Mae-UAS.6.11}Pak3LA00012 does not disrupt Pak3 transcription.

      (Ozdowski et al., 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pak3LA00012
      Name Synonyms
      Secondary FlyBase IDs
        References (2)