FB2026_02 , released June 18, 2026
Allele: Dmel\Ofut1R245A.UAS
Open Close
General Information
Symbol
Dmel\Ofut1R245A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0182456
Feature type
allele
Associated gene
Dmel\Ofut1
Associated Insertion(s)
Carried in Construct
P{UAS-Ofut1.R245A}
Also Known As
UAS-Ofut1R245A
Key Links
Transgenic product class
missense_variant
(Okajima, 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Okajima, 2005)
Mutagen
in vitro construct
(Okajima, 2005, Okajima et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Ofut1.R245A}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of O-fut1 (carries the amino acid replacement R245A).

(Okajima, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ofut1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous O-fut14R6 clones in the adult intestine which also express O-fut1R245A.Scer\UAS under the control of Scer\GAL4tub.PU show an increase in intestinal stem cell-like cells compared to wild type, without affecting the specification or differentiation of enteroendocrine cells or large enterocytes.

      (Perdigoto et al., 2011)

      Flies expressing O-fut1R245A.Scer\UAS under the control of Scer\GAL4ap-md544 produce extra microchaetae. Macrochaeta number is not affected.

      (Okajima et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      O-fut1R245A.Scer\UAS
      O-fut1R245A.UAS
      Ofut1R245A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)