FB2026_02 , released June 18, 2026
Allele: Dmel\Ofut14R6
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General Information
Symbol
Dmel\Ofut14R6
Species
D. melanogaster
Name
FlyBase ID
FBal0152355
Feature type
allele
Associated gene
Dmel\Ofut1
Associated Insertion(s)
Carried in Construct
Also Known As
o-fut14R6
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: K133term.

    (Sasamura et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:14,161,914..14,161,914 [+]
    Nucleotide change:

    A14161914T

    Amino acid change:

    K133term | O-fut1-PA; K133term | O-fut1-PB

    Reported amino acid change:

    K133term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Sasamura et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous O-fut14R6 clones in the adult intestine which also express O-fut1R245A.Scer\UAS under the control of Scer\GAL4tub.PU show an increase in intestinal stem cell-like cells compared to wild type, without affecting the specification or differentiation of enteroendocrine cells or large enterocytes.

        (Perdigoto et al., 2011)

        Embryos maternally and zygotically mutant for O-fut14R6 (generated using females carrying homozygous O-fut14R6 germline clones) exhibit a neurogenic phenotype, in which excess neurons are produced at the expense of epidermal cells.

        Embryos expressing O-fut1R245A in a maternal and zygotic O-fut14R6 mutant background exhibit normal neurogenesis. The embryos are able to hatch, but die as first instar larvae.

        (Okajima et al., 2008)

        O-fut14R6 homozygous embryos are normal with respect to neurogenesis, but embryos derived from O-fut14R6 homozygous germ-line clones show a strong neurogenic phenotype that is not significantly paternally rescued. In the adult wing, O-fut14R6 mutant clones result in loss of wing margin and vein thickening.

        (Sasamura et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Ofut14R6 is partially rescued by Ofut1hs.PS

        (Sasamura et al., 2003)
        Comments

        Expression of O-fut1R245A rescues the neurogenic defects seen in embryos that are maternally and zygotically mutant for O-fut14R6.

        (Okajima et al., 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        O-fut14R6
        (Ishio et al., 2015, Sasaki et al., 2007, Sasamura et al., 2007)
        Ofut14R6
        (Perdigoto et al., 2011, Okajima et al., 2008, Okajima, 2005, Okajima et al., 2005)
        nti
        (Lowe, 2005)
        o-fut14R6
        (Weng et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (10)