Open Close
General Information
Symbol
Dmel\NosC
Species
D. melanogaster
Name
FlyBase ID
FBal0182479
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dNOSC
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G10816228A

Reported nucleotide change:

G?A

Amino acid change:

G584E | Nos-PA; G584E | Nos-PF; G333E | Nos-PK

Reported amino acid change:

G585E

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G585E.

Nucleotide substitution: G1942A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

NosC third instar larvae exhibit significantly reduced paired pulse ratio at 20 ms ISI; significantly enhanced mEJC frequencies; and significantly increased vesicle pool size in NMJs of ventral longitudinal m6 in abdominal segments 2 and 3 when compared to controls.

A subset of NosΔ15/NosC or NosC/Nos1 mutants display pruning defects and/or precocious regrowth of axons in the mushroom body gamma-lobe, as compared to NosΔ15/+, Nos1/+ or NosC/+ controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

FlyBase curator comment: FBrf0210138 demonstrates that the lethality attributed to the NosC mutation in FBrf0180083 is in fact due to a separable second-site lethal on the chromosome.

Separable from: a secondary lethal mutation on the chromosome, which maps roughly 0.08 map units (approximately 22kb) from the NosC lesion.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)