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General Information
Symbol
Dmel\NetBunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0182503
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The connectives are farther apart than normal in the central nervous system of double mutant NetAunspecified NetBunspecified 14 hour embryos and the commissures are often missing, very thin or project towards the periphery. Commissural defects are seen in every segment. The longitudinal connectives are farther away from the midline than normal; the medial tracts are positioned about 20μm apart in 14 hour double mutant NetAunspecified NetBunspecified embryos, compared to about 9 μm apart in wild-type embryos. Earlier in development, at approximately 10 hours, the tracts from pCC neurons are projected farther away from the midline than normal in double mutant NetAunspecified NetBunspecified embryos. The longitudinal tract phenotype of double mutant NetAunspecified NetBunspecified embryos is not altered by expression of fra::roboScer\UAS.RF.T:Hsap\MYC under the control of Scer\GAL4elav.PLu. The positioning of the longitudinal tracts in sliunspecified ; NetAunspecified NetBunspecified double mutant embryos is as seen in NetAunspecified NetBunspecified mutant embryos. The positioning of the longitudinal tracts in robounspecified ; NetAunspecified NetBunspecified double mutant embryos is as seen in NetAunspecified NetBunspecified single mutant embryos.

    NetAunspecified, NetBunspecified double mutants show trajectory defects of the ISN; this fascicle stalls, show excessive branching, crosses segment boundaries and projects beyond the dorsal target muscles. The ventral ISNb innervation of muscles 6 and 7 is disrupted. Additionally, the SNa sometimes stalls or is missing one or two of the major branches. The ventral-ISNb branch projection phenotype is suppressed when unc-5Scer\UAS.T:Ivir\HA1,T:wg is expressed, under the control of Scer\GAL4elav.PLu, in a NetA, NetB double mutant background.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    NetBunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (2)