FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp70Ba304
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General Information
Symbol
Dmel\Hsp70Ba304
Species
D. melanogaster
Name
FlyBase ID
FBal0183163
Feature type
allele
Associated gene
Dmel\Hsp70Ba
Associated Insertion(s)
TI{TI}Hsp70Ba304
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Gong and Golic, 2004)
Mutagen
FLPase
(Gong and Golic, 2004)
I-SceI
(Gong and Golic, 2004)
recombination
(Gong and Golic, 2005.6.2, Gong and Golic, 2004)
ends-out gene targeting
(Gong and Golic, 2005.6.2, Gong and Golic, 2004)
Progenitor genotype
Associated Insertion(s)
TI{TI}Hsp70Ba304
Cytology
Description

Deletion of the Hsp70Ba gene.

(Gong and Golic, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hsp70Ba304 in the homozygous condition has no effect on within-individual variation quantified by fluctuating asymmetry (FA) of morphological traits. However, among-individual variation quantified by coefficient of variation (CV) of bristle number and wing size in female is significantly increased.

      (Takahashi et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(3R)Hsp70A/Hsp70Ba304 flies show reduced thermotolerance compared to wild-type flies. When flies are pretreated at 35oC for 30 min, then moved to 39oC for analysis, wild-type flies can withstand 50-60 minutes before half of them are paralyzed, while Df(3R)Hsp70A/Hsp70Ba304 flies reach this point after ~30 min. Df(3R)Hsp70A/Hsp70Ba304 larvae show a small but significant reduction in viability in response to a 35oC 30-min pretreatment, followed by incubation at 39oC for 45 min, compared to wild-type larvae. This reduction in viability can be rescued by expression of two copies of the P{>whs,3Xwt70>A} transgene.

      (Gong and Golic, 2006)
      Xenogenetic Interactions
      Statement
      Reference

      The cell death and pigment loss that occurs in the eyes flies expressing Hsap\MJDQ61.Scer\UAS under the control of Scer\GAL4GMR.PF, is enhanced in Df(3R)Hsp70A, Hsp70Ba304 flies.

      (Gong and Golic, 2006)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsp70Ba-
      (Gong and Golic, 2004)
      Hsp70Ba304
      (Takahashi et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)