FlyBase Allele Report: Hsap\APLP2[UAS.cMa]

General Information

Symbol

Hsap\APLP2^UAS.cMa

Species

H. sapiens

Name

FlyBase ID

FBal0183239

Feature type

allele

Associated gene

Hsap\APLP2

Associated Insertion(s)

Carried in Construct

P{UAS-APLP2.M}

Also Known As

UAS-APLP2

Key Links

Transgenic product class

wild_type

(Merdes et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Merdes et al., 2004)

Mutagen

in vitro construct

(Merdes et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-APLP2.M}

Cytology

Description

UAS sequences drive expression of Hsap\APLP2.

(Merdes et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\APLP2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

visible, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

visible, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

visible, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

Phenotype Manifest In

anterior crossvein | adult stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

eo neuron, with Scer\GAL4^ap-md544

(Merdes et al., 2004)

eo neuron, with Scer\GAL4^sca-537.4

(Merdes et al., 2004)

mechanosensory sensory organ, with Scer\GAL4^ap-md544

(Merdes et al., 2004)

mechanosensory sensory organ, with Scer\GAL4^sca-537.4

(Merdes et al., 2004)

scutellum | adult stage, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

thecogen cell, with Scer\GAL4^ap-md544

(Merdes et al., 2004)

thecogen cell, with Scer\GAL4^sca-537.4

(Merdes et al., 2004)

tormogen cell | ectopic, with Scer\GAL4^ap-md544

(Merdes et al., 2004)

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

(Merdes et al., 2004)

trichogen cell, with Scer\GAL4^sca-537.4

(Merdes et al., 2004)

trichogen cell | ectopic, with Scer\GAL4^ap-md544

(Merdes et al., 2004)

wing blade | adult stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

wing pouch | third instar larval stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

Detailed Description

Statement

Reference

Expression of Hsap\APLP2^Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4^ptc-559.1 leads to increased cell death in this region, along with a loss of anterior crossvein phenotype in adult fly wings, compared to controls. Expression of Hsap\APLP2^Scer\UAS.cMa driven by Scer\GAL4^sd-SG29.1 leads to cell death in the wing pouch of third instar larvae and produces a small blistered wing phenotype in adults. Expression of Hsap\APLP2^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237 leads to a small scutellum phenotype in flies, compared to controls.

(Wang et al., 2015)

When Hsap\APLP2^Scer\UAS.cMa is driven by Scer\GAL4^ap-md544 The fate of the pIIb daughters cells in the mechanosensory organ is changed to socket and shaft cells instead of the sheath and neuron as in wild-type - thus each sensory organ precursor produces 2 shafts and two sockets. Patches of naked cuticle are also seen. When Hsap\APLP2^Scer\UAS.cMa is driven by Scer\GAL4^sca-537.4 all of the sensory organ precursor grandchild cells take the socket fate. Patches of naked cuticle are also seen.

(Merdes et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30122

w¹¹¹⁸; P{UAS-APLP2.M}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\APLP2^Scer\UAS.cMa

Hsap\APLP2^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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