FlyBase Allele Report: Dmel\Glut1[d05758]

General Information

Symbol

Dmel\Glut1^d05758

Species

D. melanogaster

Name

FlyBase ID

FBal0183413

Feature type

allele

Associated gene

Dmel\Glut1

Associated Insertion(s)

P{XP}Glut1^d05758

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

P{XP}Glut1^d05758

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{XP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:959,584..959,584 [+]

(Oka et al., 2025, Vittori et al., 2014, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Vittori et al., 2014)

ameliorates Alzheimer's disease

modeled by Hsap\MAPT^V337M.UAS

(Shulman et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal tergite 5 | female

(Dembeck et al., 2015)

abdominal tergite 6 | female

(Dembeck et al., 2015)

Detailed Description

Statement

Reference

Glut1^d05758 mutant adult females display significantly increased level of pigmentation on the abdominal tergites 5 and 6 compared to controls.

(Dembeck et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Glut1^d05758, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Glut1^d05758, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Shulman et al., 2011)

NOT Suppressor of

Statement

Reference

Glut1^d05758, Scer\GAL4^elav-C155 is a non-suppressor of partially lethal - majority die phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Glut1^d05758, Scer\GAL4^elav-C155 is a suppressor of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Vittori et al., 2014)

Glut1^d05758, Scer\GAL4^GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Shulman et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Glut1^d05758 partially suppresses the rhabdomere loss seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155. Eclosion rate is not significantly altered compared to expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} alone.

(Vittori et al., 2014)

The moderate rough eye phenotype and reduced adult eye size characteristic for flies expressing Scer\GAL4^GMR.PU under the control of Hsap\MAPT^{V337M.Scer\UAS} is suppressed by co-expression of Glut1^d05758, restoring a near wild-type phenotype.

(Shulman et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Glut1^d05758

(Dembeck et al., 2015, Vittori et al., 2014, Shulman et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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