FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GαoGTP.hs
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General Information
Symbol
Dmel\GαoGTP.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0183486
Feature type
allele
Associated gene
Dmel\Gαo
Associated Insertion(s)
Carried in Construct
P{hs-Gαo.GTP}
Key Links
Transgenic product class
missense_variant
(Katanaev et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Katanaev et al., 2005)
Mutagen
in vitro construct
(Katanaev et al., 2005)
Progenitor genotype
Carried in construct
P{hs-Gαo.GTP}
Cytology
Description

Construct: Amino acid replacement: Q205L. Nucleotide substitution: A?T. A heat shock promoter drives expression of a mutated form of G-oα47A which is maintained in the GTP bound state.

(Katanaev et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Gαo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of G-oα47AGTP.hs in embryos using heat shock results in a loss of denticles phenotype.

      (Katanaev et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      GαoGTP.hs is a non-suppressor of embryonic/first instar larval cuticle phenotype of arm2

      (Katanaev et al., 2005)

      GαoGTP.hs is a non-suppressor of ventral denticle belt phenotype of arm2

      (Katanaev et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lawn of denticles phenotype seen in arm2/Y embryos is not affected by expression of G-oα47AGTP.hs using heat shock.

      (Katanaev et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      G-oα47AGTP.hs
      GαoGTP.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)