FlyBase Allele Report: Dmel\Csp[DG29203]

General Information

Symbol

Dmel\Csp^DG29203

Species

D. melanogaster

Name

FlyBase ID

FBal0184280

Feature type

allele

Associated gene

Dmel\Csp

Associated Insertion(s)

P{wHy}Csp^DG29203

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Wishart et al., 2012)

Mutagen

P-element activity

(Gelbart, 2008.3.31)

Progenitor genotype

Associated Insertion(s)

P{wHy}Csp^DG29203

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:22,267,563..22,267,563 [+]

(Brusich et al., 2015, Wishart et al., 2012, Gelbart, 2008.3.31, Myrick et al., 2005.5.16)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | conditional

(Wishart et al., 2012)

abnormal neuroanatomy | conditional (with Csp^X1)

(Wishart et al., 2012)

Phenotype Manifest In

olfactory receptor neuron | conditional

(Wishart et al., 2012)

olfactory receptor neuron | conditional (with Csp^X1)

(Wishart et al., 2012)

Detailed Description

Statement

Reference

The olfactory receptor neurons of Csp^DG29203 mutants show a partial delay in degeneration of distal axons and synaptic terminals following surgical ablation of the antennae.

(Wishart et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Csp[+]/Csp^DG29203 is an enhancer of abnormal neurophysiology phenotype of GluRIIA^SP16, cac^S/cac[+]

(Brusich et al., 2015)

Other

Statement

Reference

Csp^DG29203, GluRIIA^SP16 has abnormal neurophysiology phenotype

(Brusich et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Csp^DG29203 prevents the compensatory increase in quantal content seen in the NMJs of cac^S/+; GluRIIA^SP16 mutant larvae that have reduced quantal size, resulting in impaired evoked neurotransmission. There is no increase in quantal content compared with cac^S/+; Csp^DG29203/+ controls.

Synaptic homeostasis is impaired in the NMJs of GluRIIA^SP16 Csp^DG29203 double mutant larvae compared with either mutant alone. The double mutant larvae show the decreased quantal size seen in GluRIIA^SP16 mutants but the usual compensatory upregulation of quantal content is not seen: quantal content is not increased compared with Csp^DG29203 mutants alone. As a result, evoked postsynaptic excitation is impaired.

(Brusich et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Csp^X1

(Wishart et al., 2012)

Comments

Df(3L)Exel6138 fails to complement the delay in axonal degeneration seen in Csp^DG29203 mutants, but the phenotype is more severe in Df(3L)Exel6138/Csp^DG29203 mutants than in Csp^DG29203 homozygotes.

Csp^X1 fails to complement the delay in axonal degeneration seen in Csp^DG29203 mutants, but the phenotype is more severe in Csp^DG29203/Csp^X1 mutants than in Csp^DG29203 homozygotes.

(Wishart et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Csp^DG29203

(Brusich et al., 2015)

csp^DG29203

(Wishart et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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