FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SERCAKum170.UAS
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General Information
Symbol
Dmel\SERCAKum170.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0184442
Feature type
allele
Associated gene
Dmel\SERCA
Associated Insertion(s)
Carried in Construct
P{UAS-SERCA.Kum170}
Also Known As
UAS-CaP60AKum170
Key Links
Transgenic product class
missense_variant
(Sanyal et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sanyal et al., 2005)
Mutagen
in vitro construct
(Sanyal et al., 2005)
Progenitor genotype
SERCAKum170
(Sanyal et al., 2005)
Carried in construct
P{UAS-SERCA.Kum170}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of SERCA that carries the amino acid replacement E442K (the lesion that is present in SERCAKum170).

(Sanyal et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
SERCA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ca-P60AKum170.Scer\UAS under the control of either Scer\GAL4elav-C155, Scer\GAL4Cha.7.4, Scer\GAL4C380, Scer\GAL4arm.PS or Scer\GAL4shi.PS does not result in any observable paralysis in either larvae or adults which have been incubated at the restrictive temperature of 40oC for 3 minutes. Expression of Ca-P60AKum170.Scer\UAS under the control of either Scer\GAL4αTub84B.PL, Scer\GAL4Mhc.PW or Scer\GAL4how-24B results in paralysis in larvae which have been incubated at the restrictive temperature of 40oC for 3 minutes, but does not result in adult paralysis at this temperature. Expression of Ca-P60AKum170.Scer\UAS under the control of Scer\GAL4Mef2.PR results in paralysis in larvae or adults which have been incubated at the restrictive temperature of 40oC for 3 minutes. The dorsal longitudinal muscles (DLMs) of adults expressing Ca-P60AKum170.Scer\UAS under the control of Scer\GAL4Mef2.PR show broadening of spontaneous action potentials with occasional failures at the restrictive temperature. At this temperature, evoked responses also show defects; spike broadening is followed by frequent failures.

      (Sanyal et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ca-P60AKum170.Scer\UAS does not rescue the reduction in lipid droplet size seen in Seipinnull mutant fat body cells.

      (Bi et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ca-P60AKum170.Scer\UAS
      SERCAKum170.Scer\UAS
      SERCAKum170.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)