FB2026_02 , released June 18, 2026
Allele: Dmel\Nbrf02257
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General Information
Symbol
Dmel\Nbrf02257
Species
D. melanogaster
Name
FlyBase ID
FBal0184635
Feature type
allele
Associated gene
Dmel\Nbr
Associated Insertion(s)
PBac{WH}Nbrf02257
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Feltzin et al., 2015, Liu et al., 2011)

hypomorphic allele - molecular evidence

(Han et al., 2011)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Nbrf02257
Cytology
Description

Nbrf02257 homozygotes produce 38% +/- 24% of the amount of Nbr mRNA present in controls.

(Han et al., 2011)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nbrf02257/Df(2L)BSC312 flies do not show significant defects in ovary development and number of eggs laid per day at different ages is similar to rescued controls. Nbrf02257/Df(2L)BSC312 flies have an age-dependent held up wing phenotype: at eclosion wings are normal but by day 5, 50% of flies show the phenotype (getting progressively worse by day 20, when 90% of flies have held up wings). Nbrf02257/Df(2L)BSC312 flies show age-dependent brain vacuolization (brains have a similar vacuole count to wild type at day 3 but show a significant increase at day 30) and progressive defects in climbing ability (significant by day 20)

      (Feltzin et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Nbrf02257/Df(2L)BSC312 is rescued by Nbr+tFa

      (Feltzin et al., 2015)
      Not rescued by

      Nbrf02257/Df(2L)BSC312 is not rescued by NbrD435A.E437A

      (Feltzin et al., 2015)
      Comments

      Nbr+tFa but not NbrD435A.E437A rescues the progressive held up wing, brain vacuolization and locomotor phenotypes in Nbrf02257/Df(2L)BSC312 flies; in terms of locomotor defects, NbrD435A.E437A leads to significant defects compared to controls at all ages (including the first time point tested, day 2).

      (Feltzin et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG9247f02257
      Nbrf02257
      nbrf02257
      (Feltzin et al., 2015, Han et al., 2011, Liu et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)