FlyBase Allele Report: Dmel\Dscam3[c02826]

General Information

Symbol

Dmel\Dscam3^c02826

Species

D. melanogaster

Name

FlyBase ID

FBal0186388

Feature type

allele

Associated gene

Dmel\Dscam3

Associated Insertion(s)

PBac{PB}Dscam3^c02826

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

PBac{PB}Dscam3^c02826

Cytology

Description

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:17,478,339..17,478,339 [+]

(Andrews et al., 2008, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Andrews et al., 2008)

Phenotype Manifest In

symmetrical commissure

(Andrews et al., 2008)

Detailed Description

Statement

Reference

44% of segments fail to separate the anterior and posterior commissures correctly in Dscam3^c02826 embryos.

(Andrews et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dscam1⁰⁵⁵¹⁸/Dscam3^c02826 is an enhancer of abnormal neuroanatomy phenotype of fra^unspecified

(Andrews et al., 2008)

NOT Enhancer of

Statement

Reference

Dscam3^c02826/Dscam3^c02826 is a non-enhancer of abnormal neuroanatomy phenotype of Dscam1⁰⁵⁵¹⁸, fra⁴

(Andrews et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dscam1⁰⁵⁵¹⁸/Dscam3^c02826 is an enhancer of SP1 neuron phenotype of fra^unspecified

(Andrews et al., 2008)

NOT Enhancer of

Statement

Reference

Dscam3^c02826/Dscam3^c02826 is a non-enhancer of Bolwig nerve phenotype of Dscam1⁰⁵⁵¹⁸, fra⁴

(Andrews et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the axon guidance defect phenotype that is seen in the Bolwig's nerve of Dscam⁰⁵⁵¹⁸/Dscam⁰⁵⁵¹⁸ fra⁴/fra⁴ double mutant embryos is not increased by addition of Dscam3^c02826/Dscam3^c02826.

84% of segments fail to separate the anterior and posterior commissures correctly in Dscam⁰⁵⁵¹⁸ Dscam3^c02826 embryos.

fra³/fra⁴ Dscam3^c02826 embryos show defects in the commissures of the central nervous system; 2% of anterior commissures are absent, 3% of anterior commissures are thin, 1% of posterior commissures are absent and 9% of posterior commissures are thin. 48% of segments fail to separate the anterior and posterior commissures correctly.

Dscam3^c02826 Abl⁴ embryos show defects in the commissures of the central nervous system; 1% of anterior commissures are absent and 2% of posterior commissures are absent. 85% of segments fail to separate the anterior and posterior commissures correctly.

Dscam⁰⁵⁵¹⁸ fra⁴ Dscam3^c02826 embryos show defects in the commissures of the central nervous system; 39% of anterior commissures are absent, 51% of anterior commissures are thin, 36% of posterior commissures are absent and 55% of posterior commissures are thin. 5% of segments fail to separate the anterior and posterior commissures correctly.

The severity of the SP1 axon midline crossing defects seen in fra^unspecified embryos is enhanced in fra^unspecified Dscam⁰⁵⁵¹⁸ Dscam3^c02826 triple mutants.

(Andrews et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: CG7433^c02826.

(Andrews et al., 2008)

Separable from: PBac{PB}CG7433^c02826.

(Gene Disruption Project members and Exelixis, 2005)

The "c02826" line has two insertions - one in Dscam3 and a second in CG7433.

(Andrews et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG31190^c02826

Dscam3¹

(Andrews et al., 2008)

Dscam3^c02826

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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