FlyBase Allele Report: Dmel\Tailor[f05717]

General Information

Symbol

Dmel\Tailor^f05717

Species

D. melanogaster

Name

FlyBase ID

FBal0187777

Feature type

allele

Associated gene

Dmel\Tailor

Associated Insertion(s)

PBac{WH}Tailor^f05717

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Tailor^f05717

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:7,084,714..7,084,752 [-]

(Reimão-Pinto et al., 2015, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with Tailor^c4-6)

(Reimão-Pinto et al., 2015)

male semi-sterile (with Tailor^c4-6)

(Reimão-Pinto et al., 2015)

semi-fertile (with Tailor^c4-1)

(Lin et al., 2017)

semi-fertile (with Tailor^c4-6)

(Lin et al., 2017)

Phenotype Manifest In

cystic bulge (with Tailor^c4-6)

(Lin et al., 2017)

individualization stage spermatid (with Tailor^c4-6)

(Lin et al., 2017)

seminal vesicle (with Tailor^c4-6)

(Lin et al., 2017)

sperm individualization complex (with Tailor^c4-6)

(Lin et al., 2017)

Detailed Description

Statement

Reference

Tailor^f05717/Tailor^c4-1 as well as Tailor^f05717/Tailor^c4-6 transheterozygotes show significant decrease in both male and female fertility compared to controls.

The germline stem cell (GSCs) niche in the Tailor^f05717/Tailor^c4-6 testes is not apparently perturbed and the number of GSCs contacting the somatic hub is similar to wild-type controls but the spermatid differentiation is impaired: the mutants display mild individualization complex scattering during the individualization process. The mutants also show smaller seminal vesicles (reflecting the reduction in sperm production) compared to controls.

(Lin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tailor^c4-1/Tailor^f05717 has semi-fertile phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has semi-fertile phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Enhancer of

Statement

Reference

Tailor^c4-1/Tailor^f05717 is an enhancer of semi-sterile phenotype of Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 is an enhancer of semi-sterile phenotype of Dis3l2^SK5

(Lin et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Tailor^f05717/Tailor^c4-6 has individualization stage spermatid phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has sperm individualization complex phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has cystic bulge phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has seminal vesicle phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The subfertility of Tailor^f05717/Tailor^c4-1 or Tailor^f05717/Tailor^c4-6 mutants and of the Dis3l2^SK5 homozygous mutants is exacerbated further in double mutants and the Tailor^f05717/Tailor^c4-1;Dis3l2^SK5/Dis3l2^SK5 or Tailor^f05717/Tailor^c4-6;Dis3l2^SK5/Dis3l2^SK5 double mutants are completely sterile.

The spermatid differentiation defects observed in testes of Tailor^f05717/Tailor^c4-6 mutant males are enhanced by combination with two copies of Dis3l2^SK5 : Like in the Dis3l2^SK5 single mutants, no cystic bulges or waste bags are formed and the double mutants bear only rudimentary seminal vesicles devoid of mature sperm.

(Lin et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

85240

w¹¹¹⁸; PBac{WH}Tailor^f05717

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG1091^f05717

(Reimão-Pinto et al., 2015)

Tailor^f05717

Tailor[f05717]

(Lin et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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