FlyBase Allele Report: Dmel\Tailor[c4-6]

General Information

Symbol

Dmel\Tailor^c4-6

Species

D. melanogaster

Name

FlyBase ID

FBal0314793

Feature type

allele

Associated gene

Dmel\Tailor

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Reimão-Pinto et al., 2015)

Mutagen

CRISPR/Cas9

(Reimão-Pinto et al., 2015)

Progenitor genotype

Cytology

Description

A 7bp deletion that results in a frame shift in the third exon of Tailor.

(Reimão-Pinto et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with Tailor^c4-1)

(Reimão-Pinto et al., 2015)

female semi-sterile (with Tailor^f05717)

(Reimão-Pinto et al., 2015)

male semi-sterile (with Tailor^c4-1)

(Reimão-Pinto et al., 2015)

male semi-sterile (with Tailor^f05717)

(Reimão-Pinto et al., 2015)

semi-fertile (with Tailor^f05717)

(Lin et al., 2017)

Phenotype Manifest In

cystic bulge (with Tailor^f05717)

(Lin et al., 2017)

individualization stage spermatid (with Tailor^f05717)

(Lin et al., 2017)

seminal vesicle (with Tailor^f05717)

(Lin et al., 2017)

sperm individualization complex (with Tailor^f05717)

(Lin et al., 2017)

Detailed Description

Statement

Reference

Tailor^f05717/Tailor^c4-6 transheterozygotes show significant decrease in both male and female fertility compared to controls.

The germline stem cell (GSCs) niche in the Tailor^f05717/Tailor^c4-6 testes is not apparently perturbed and the number of GSCs contacting the somatic hub is similar to wild-type controls but the spermatid differentiation is impaired: the mutants display mild individualization complex scattering during the individualization process. The mutants also show smaller seminal vesicles (reflecting the reduction in sperm production) compared to controls.

(Lin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tailor^f05717/Tailor^c4-6 has semi-fertile phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Enhancer of

Statement

Reference

Tailor^f05717/Tailor^c4-6 is an enhancer of semi-sterile phenotype of Dis3l2^SK5

(Lin et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Tailor^f05717/Tailor^c4-6 has individualization stage spermatid phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has sperm individualization complex phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has cystic bulge phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Tailor^f05717/Tailor^c4-6 has seminal vesicle phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The subfertility of Tailor^f05717/Tailor^c4-6 transheterozygous and Dis3l2^SK5 homozygous mutants is exacerbated further in the double mutants and the Tailor^f05717/Tailor^c4-6;Dis3l2^SK5/Dis3l2^SK5 flies (males as well as females) are completely sterile.

The spermatid differentiation defects observed in testes of Tailor^f05717/Tailor^c4-6 mutant males are enhanced by combination with two copies of Dis3l2^SK5 : Like in the Dis3l2^SK5 single mutants, no cystic bulges or waste bags are formed and the double mutants bear only rudimentary seminal vesicles devoid of mature sperm.

(Lin et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tailor^c4-6

Tailor[c4-6]

(Lin et al., 2017)

tailor^c4-6

(Reimão-Pinto et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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