FB2026_02 , released June 18, 2026
Allele: Dmel\knk3-7H
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General Information
Symbol
Dmel\knk3-7H
Species
D. melanogaster
Name
FlyBase ID
FBal0189669
Feature type
allele
Associated gene
Dmel\knk
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Moussian et al., 2006)
Progenitor genotype
Cytology
Description

knk3-7H encodes a severely truncated 32 amino acid protein.

(Moussian et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The inner two layers of the cuticle (epicuticle and procuticle) appear to have mixed in mutant larvae, resulting in bloated animals that die before hatching.

      (Gangishetti et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      knk1/knk3-7H is rescued by knk+t9.5

      (Shaik et al., 2014)
      Partially rescued by

      knk1/knk3-7H is partially rescued by knkR401G

      (Shaik et al., 2014)
      Not rescued by

      knk1/knk3-7H is not rescued by knkW299G

      (Shaik et al., 2014)

      knk1/knk3-7H is not rescued by knkM333V

      (Shaik et al., 2014)

      knk1/knk3-7H is not rescued by knkH437S

      (Shaik et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Slawek Bartoszewsk

      (Moussian et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      knk3-7H
      (Shaik et al., 2014, Gangishetti et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)