FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Smox1
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General Information
Symbol
Dmel\Smox1
Species
D. melanogaster
Name
FlyBase ID
FBal0189928
Feature type
allele
Associated gene
Dmel\Smox
Associated Insertion(s)
Carried in Construct
Also Known As
dSmad21
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Smox1 mutant MARCM clone R7 axons exhibit tiling defects where they invade adjacent targets. The patterning of Smox1 mutant eye discs appears wild-type.

        (Ting et al., 2007)

        Smox1 mutant dorsal cluster neuron clones display various anomalies. These defects include arrest of most axons at the protocerebrum---optic lobe junction, overextension of neurites from the ipsilateral lobular complex, ectopic projections in the central brain and aberrant fasciculation of processes.

        (Zheng et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Suppressor of
        Statement
        Reference

        Smox1/Smox[+] is a non-suppressor of abnormal locomotor behavior | heat sensitive phenotype of Hsap\TOR1AΔE.UAS, Scer\GAL4elav-C155

        (Koh et al., 2004)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The locomotor defects in flies expressing Hsap\TOR1AΔE.Scer\UAS under the control of Scer\GAL4elav-C155 observed at 38[o]C are not enhanced in a Smox1/+ background

        (Koh et al., 2004)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Smox1
        dSmad21
        (Wang et al., 2019, Ting et al., 2007, Koh et al., 2004)
        dSmad1
        (Zheng et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)