FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\chnUAS.cEa
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General Information
Symbol
Dmel\chnUAS.cEa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Escudero
FlyBase ID
FBal0190145
Feature type
allele
Associated gene
Dmel\chn
Associated Insertion(s)
Carried in Construct
P{UAS-chn.E}
Also Known As
UAS-chn
Key Links
Transgenic product class
cDNA
(Escudero et al., 2005)
wild_type
(Escudero et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Escudero et al., 2005)
wild_type
(Escudero et al., 2005)
Mutagen
in vitro construct
(Escudero et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-chn.E}
Cytology
Description

UASt regulatory sequences drive expression of the chn SD05496 cDNA.

(Escudero et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
chn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult head bristle | ectopic, with Scer\GAL4MS248

      (Escudero et al., 2005)

      dorsal mesothoracic disc & sensory mother cell | ectopic, with Scer\GAL4Bx-MS1096

      (Escudero et al., 2005)

      dorsal mesothoracic disc & sensory mother cell | ectopic, with Scer\GAL4MS248

      (Escudero et al., 2005)

      macrochaeta | ectopic, with Scer\GAL4C-765

      (Escudero et al., 2005)

      mesonotum, with Scer\GAL4MS248

      (Escudero et al., 2005)

      mesothoracic tergum & macrochaeta | ectopic, with Scer\GAL4MS248

      (Escudero et al., 2005)

      metathoracic bristle | ectopic, with Scer\GAL4Bx-MS1096

      (Escudero et al., 2005)

      microchaeta | ectopic, with Scer\GAL4C-765

      (Escudero et al., 2005)

      wing & chaeta | ectopic, with Scer\GAL4Bx-MS1096

      (Escudero et al., 2005)

      wing & chaeta | ectopic, with Scer\GAL4C-765

      (Escudero et al., 2005)
      Detailed Description
      Statement
      Reference

      Expression of chnScer\UAS.cEa under the control of Scer\GAL4C-765 at 18oC results in extra bristles, with the appearance of many extra macrochaetae near wild-type bristles and an increase in the density of microchaetae on the notum. The bristles are always separated by epidermal cells in these flies. In addition, extra bristles are formed on the wings. At 25oC, most of these animals die before the pharate stage. Expression of chnScer\UAS.cEa under the control of Scer\GAL4MS248 reduces the size of the heminota and interferes with their dorsal fusion. In addition, extra macrochaetae are formed on the notum and on the head. Third instar wing discs expressing chnScer\UAS.cEa under the control of Scer\GAL4MS248 contain many ectopic sensory organ precursor cells (SOPs). The extra bristle and heminota fusion phenotypes caused by expression of chnScer\UAS.cEa under the control of Scer\GAL4MS248 are largely rescued by co-expression of chndsRNA.Scer\UAS (strong expressing line P{UAS-chn.dsRNA}S). Expression of chnScer\UAS.cEa under the control of Scer\GAL4Bx-MS1096 results in extra bristles on the wing and metathorax. Third instar wing discs expressing chnScer\UAS.cEa under the control of Scer\GAL4Bx-MS1096 contain ectopic SOPs. Expression of chnScer\UAS.cEa under the control of Scer\GAL4da.G32, Scer\GAL41407 or Scer\GAL469B does not appreciably affect the larval peripheral nervous system.

      (Escudero et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      chnUAS.cEa/Scer\GAL469B partially rescues chnECJ1

      (Escudero et al., 2005)
      Comments

      The peripheral nervous system phenotypes seen in homozygous chnECJ1 embryos are largely rescued by expression of chnScer\UAS.cEa under the control of Scer\GAL469B.

      (Escudero et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      chnScer\UAS.cEa
      chnUAS.cEa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Escudero
      (Escudero et al., 2005)
      Secondary FlyBase IDs
        References (2)