FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam120
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General Information
Symbol
Dmel\Dscam120
Species
D. melanogaster
Name
FlyBase ID
FBal0190217
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
Also Known As
Dscam20
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Watson et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        anterior scutellar bristle & mechanosensory neuron | somatic clone

        (Chen et al., 2006)

        embryonic/larval hemocyte (with Dscam139)

        (Watson et al., 2005)

        medulla | larval stage | somatic clone

        (Liu et al., 2020)

        medulla | P-stage | somatic clone

        (Liu et al., 2020)

        neurite | larval stage | somatic clone

        (Liu et al., 2020)

        posterior dorsocentral bristle & mechanosensory neuron | somatic clone

        (Chen et al., 2006)

        posterior scutellar bristle & mechanosensory neuron | somatic clone

        (Chen et al., 2006)
        Detailed Description
        Statement
        Reference

        Dscam20 posterior Dorsocentral (pDc), anterior Scutellar (aSc) and posterior Scutellar (pSc) neuron clones enter the thoracic ganglion at the correct position but are unable to correctly target axonal branches and fail to elaborate any arbors. These neurons are able to form axonal branches but these remain clustered in a small bolus around a presumptive decision point. This phenotype is 100% penetrant for all tested neuron clones.

        (Chen et al., 2006)

        Dscam20/Dscam39 larval hemocytes show a significant reduction in phagocytosis of heat-killed E.coli compared to wild-type hemocytes.

        (Watson et al., 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Dscam120 is rescued by Dscam1+tCH321-22M14

        (Venken et al., 2009)

        Dscam120/Dscam121 is rescued by Dscam1+tCH321-22M14

        (Venken et al., 2009)

        Dscam120/Dscam123 is rescued by Dscam1+tCH321-22M14

        (Venken et al., 2009)
        Partially rescued by

        Dscam120 is partially rescued by Dscam11.34.30.2.UAS/Scer\GAL4elav.PLu

        (Chen et al., 2006)

        Dscam120 is partially rescued by Dscam11.30.30.2.A.UAS/Scer\GAL4elav.PLu

        (Chen et al., 2006)

        Dscam120 is partially rescued by Dscam17.6.19.2.UAS/Scer\GAL4elav.PLu

        (Chen et al., 2006)
        Comments

        Expression of transgenes that encode different isoforms of Dscam, under the control of Scer\GAL4elav.PLu, partially rescue the axonal targeting phenotype of Dscam20 mechanosensory clones. Both the Dscam1.34.30.2.Scer\UAS and Dscam7.6.19.2.Scer\UAS transgenes rescue primary axon extension posteriorly. Occasionally, Dscam1.30.30.2.A.Scer\UAS rescues the proximal, anterior-extending secondary axonal branch and a distal ipsilateral branch.

        (Chen et al., 2006)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        DScam20
        (Venken, 2006)
        Dscam120
        Dscam20
        (Venken et al., 2009, Chen et al., 2006)
        dscam20
        (Liu et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)