FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Met253
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General Information
Symbol
Dmel\Met253
Species
D. melanogaster
Name
FlyBase ID
FBal0190347
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: S705G.

    (Wilson et al., 2006)

    Amino acid replacement: A600T.

    (Wilson et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:11,618,734..11,618,734 [+]
    Nucleotide change:

    G11618734A

    Amino acid change:

    A600T | Met-PA; A600T | Met-PB

    Reported amino acid change:

    A600T

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Wilson et al., 2006)
    point_mutation
    X:11,619,049..11,619,049 [+]
    Nucleotide change:

    A11619049G

    Amino acid change:

    S705G | Met-PA; S705G | Met-PB

    Reported amino acid change:

    S705G

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Wilson et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes show increased resistance to methoprene compared to controls.

        Homozygous females have a reduced rate of oviposition compared to controls.

        20% of mutant flies have a small number of defective ommatidia in the posterior quarter of the eye.

        (Wilson et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Met253, br1 has some die during P-stage phenotype

        (Wilson et al., 2006)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Met253/Met253 is an enhancer of ovary phenotype of br1

        (Wilson et al., 2006)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        br1, Rst(1)JH253 double mutant escapers show significantly reduced levels of oogenesis compared to br1 single mutants.

        (Wilson et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Met253
        (Wilson et al., 2006, Wilson et al., 2006)
        Rst(1)JH253
        Name Synonyms
        Secondary FlyBase IDs
          References (2)