FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\crbT6DT9D.intra.UAS
Open Close
General Information
Symbol
Dmel\crbT6DT9D.intra.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190526
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
P{UAS-crb-intra.T6DT9D}
Key Links
Transgenic product class
inframe_deletion
(Sotillos et al., 2004)
missense_variant
(Sotillos et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Sotillos et al., 2004)
missense_variant
(Sotillos et al., 2004)
Mutagen
in vitro construct
(Sotillos et al., 2004)
Progenitor genotype
crbintra.UAS
(Sotillos et al., 2004)
Carried in construct
P{UAS-crb-intra.T6DT9D}
Cytology
Description

Construct: Amino acid replacement: T6D. Amino acid replacement: T9D.

(Sotillos et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
crb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dorsal mesothoracic disc & epithelial cell, with Scer\GAL4en-e16E

      (Sotillos et al., 2004)
      Detailed Description
      Statement
      Reference

      Overexpression of crbT6DT9D.intra.Scer\UAS, under the regulation of Scer\GAL4en-e16E in the imaginal discs disrupts the wing epithelium, with disorganisation of the wing tissue being attributable to apicalisation of the wing disc cells and causes strong cuticular defects.

      (Sotillos et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of kinase-dead aPKCCAAXDN.Scer\UAS, under the regulation of Scer\GAL4en-e16E normalises the effect caused by overexpression of wild-type crbT6DT9D.intra.Scer\UAS (under the control of Scer\GAL4en-e16E) in approximately 40% of the flies, even though these flies still display strong cuticular defects

      (Sotillos et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      crbT6DT9D.intra.Scer\UAS
      crbT6DT9D.intra.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)