FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fzJB
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General Information
Symbol
Dmel\fzJB
Species
D. melanogaster
Name
FlyBase ID
FBal0190610
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl nitrosourea
(Povelones et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: W355term.

(Povelones et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:14,317,188..14,317,188 [+]
Nucleotide change:

G14317188A

Amino acid change:

W355term | fz-PA; W355term | fz-PC

Reported amino acid change:

W355term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Povelones et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  acute myeloid leukemia
      modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
      (Sinenko et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of fzJB has no effect on hemocyte proliferation in third instar larvae.

      (Sinenko et al., 2010)

      fzJB has a strong multiple wing hair phenotype in combination with fz30.

      (Povelones et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Suppressor of
      Statement
      Reference

      fzJB/fz[+] is a suppressor | partially of visible | adult stage phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Lee et al., 2020)

      fzJB/fz[+] is a suppressor | partially of decreased size | adult stage phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Lee et al., 2020)
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Statement
      Reference

      fzJB/fz[+] is a suppressor | partially of eye phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Lee et al., 2020)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos that lack zygotic fz and fz2 function which are derived from fzJB/fzGL31 fz2e2 females mated to fzGL31 fz2e2/+ males are dramatically shortened and lack naked cuticle.

      (Povelones et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      One copy of fzJB strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

      (Sinenko et al., 2010)
      Complementation and Rescue Data
      Fails to complement

      fz30

      (Povelones et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fzJB
      (Lee et al., 2020, Sinenko et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)