FB2026_02 , released June 18, 2026
Allele: Dmel\ShSDN.UAS
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General Information
Symbol
Dmel\ShSDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190651
Feature type
allele
Associated gene
Dmel\Sh
Associated Insertion(s)
Carried in Construct
P{UAS-SDN}
Also Known As
UAS-SDN
Key Links
Transgenic product class
dominant_negative_variant
(Mosca et al., 2005)
inframe_deletion
(Mosca et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Mosca et al., 2005)
inframe_deletion
(Mosca et al., 2005)
Mutagen
in vitro construct
(Mosca et al., 2005)
Progenitor genotype
ShEKO.UAS.GFP(GL)
(Mosca et al., 2005)
Carried in construct
P{UAS-SDN}
Cytology
Description

UAS regulatory sequences drive expression of a dominant-negative form of Sh that lacks the N-terminal inactivation domain and all sequence 3' to the S1 transmembrane helix (amino acids 30-246 are present).

(Mosca et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ShSDN.Scer\UAS under the control of Scer\GAL4Tdc2.PC in type II neurons in an eag1 mutant background results in an increase in the number of natural synaptopods and type II boutons and terminal branches.

      (Koon et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ShSDN.Scer\UAS
      ShSDN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)