FlyBase Allele Report: Dmel\dlp[MH20]

General Information

Symbol

Dmel\dlp^MH20

Species

D. melanogaster

Name

FlyBase ID

FBal0190712

Feature type

allele

Associated gene

Dmel\dlp

Associated Insertion(s)

Carried in Construct

Also Known As

dlp²⁰

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Franch-Marro et al., 2005)

Mutagen

P-element activity

(Franch-Marro et al., 2005)

Progenitor genotype

Cytology

Description

Deletion extending from -42 to +467 relative to the dlp transcription start site. Generated by imprecise excision of a P{GSV6} insertion located upstream of the transcription unit.

(Franch-Marro et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:14,632,559..14,633,068 [+]

Comment:

Deletion resulting from the imprecise excision of P{GSV6} that extends from -42 to +467 relative to the dlp transcription start site.

(Franch-Marro et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Kakugawa et al., 2015)

lethal | recessive

(Gallet et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

In dlp^MH20 mutants, the number of ectopic mechanosensory bristles, but not chemosensory bristles, is increased.

(You et al., 2011)

Less than 1% of homozygous third instar larvae reach adulthood.

Wings from homozygous escapers are reduced in size compared to controls, with a greater reduction in the intervein area between wing veins 3 and 4 compared to the reduction in overall wing size. Ectopic mechanosensory bristles are present at the anterior wing margin. Homozygous adult escapers also have reduced, rough eyes.

(Gallet et al., 2008)

Mutant embryos die with a "denticle lawn" phenotype. A low frequency of animals survive to adulthood. Those adults exhibit supernumerary wing margin bristles on either side of the margin.

(Franch-Marro et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

dlp^MH20 has mechanosensory chaeta | increased number phenotype, enhanceable by Sulf1^Δ1

(You et al., 2011)

dlp^MH20 has ventral denticle belt phenotype, enhanceable by dally^MH32

(Franch-Marro et al., 2005)

dlp^MH20 has embryonic/first instar larval cuticle phenotype, enhanceable by dally^MH32

(Franch-Marro et al., 2005)

NOT Enhancer of

Statement

Reference

dlp[+]/dlp^MH20 is a non-enhancer of wing margin taste bristle | decreased number phenotype of peg^Del1

(Magny et al., 2021)

NOT Suppressor of

Statement

Reference

dlp[+]/dlp^MH20 is a non-suppressor of wing margin taste bristle | decreased number phenotype of peg^Del1

(Magny et al., 2021)

dlp^MH20 is a non-suppressor of taste bristle | increased number phenotype of Sulf1^Δ1

(You et al., 2011)

dlp^MH20 is a non-suppressor of mechanosensory chaeta | increased number phenotype of Sulf1^Δ1

(You et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

In dlp^MH20 Sulf1^Δ1 double mutants the number of ectopic mechanosensory bristles is increased.

(You et al., 2011)

Embryos mutant for both zygotic and maternal dlp^MH20 and dally^MH32 (dlp^MH20, dally^MH32) exhibit a denticle phenotype stronger than seen in dally^MH32 mutants and exhibit mid-ventral denticle whorls.

(Franch-Marro et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dlp^MH20 is rescued by dlp^{Tub.Tag:M(mCd8a),GFP}

(Kakugawa et al., 2015)

dlp^MH20 is rescued by Scer\GAL4^ptc-559.1/dlp^{UAS.Tag:SS(wg),GFP}

(Gallet et al., 2008)

Not rescued by

dlp^MH20 is not rescued by Scer\GAL4^ptc-559.1/dlp^{UAS.GFP,Tag:M(rCd2)}

(Gallet et al., 2008)

Comments

Expression of dlp^{Scer\UAS.T:wg,T:Avic\GFP} under the control of Scer\GAL4^ptc-559.1 significantly rescues the reduction of the vein 3-4 intervein space that is seen in the wings of dlp^MH20 escapers.

Expression of dlp^{Scer\UAS.T:Avic\GFP,T:Rnor\CD2} under the control of Scer\GAL4^ptc-559.1 does not rescue the reduction of the vein 3-4 intervein space that is seen in the wings of dlp^MH20 escapers.

(Gallet et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98350

w^*; dlp^MH20 P{FRT(w^hs)}2A/TM6B, Tb⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dlp²⁰

(Simon et al., 2021, González-Méndez et al., 2017, Norman et al., 2016, Ayers et al., 2012, Sánchez-Hernández et al., 2012, Gallet et al., 2008)

dlp^MH20

(Nakato et al., 2024, Magny et al., 2021, McGough et al., 2020, Yamazaki et al., 2016, Kakugawa et al., 2015, Avanesov and Blair, 2013, Callejo et al., 2011, Wojcinski et al., 2011, You et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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