FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dronc2
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General Information
Symbol
Dmel\Dronc2
Species
D. melanogaster
Name
FlyBase ID
FBal0190807
Feature type
allele
Associated gene
Dmel\Dronc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Xu et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: L325term.

(Xu et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:9,970,370..9,970,370 [+]
Nucleotide change:

T9970370A

Amino acid change:

L325term | Dronc-PA

Reported amino acid change:

L325term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Xu et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nc2 mutant eye clones are significantly larger than their wild-type twin spots.

      Nc2 mutant eye clones induce ectopic cell proliferation posterior to the second mitotic wave in the eye-antennal disc.

      Nc2 mutant eye clones exhibit extra ommatidial pigment cells in the pupal retina.

      (Verghese et al., 2012)

      Nc2/Nc51 mutant third instar larvae have melanotic nodules found in the hemocoel or in association with He-positive lymph glands. They also show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.

      Nc2/Df(3L)AC1 show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.

      (Minakhina and Steward, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Dronc2/Dronc2 is a suppressor of visible | somatic clone phenotype of hidGMR.PG

      (Xu et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Dronc2/Dronc2 is a suppressor of eye | somatic clone phenotype of hidGMR.PG

      (Xu et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a recessive suppressor of the WGMR.PG eye ablation phenotype.

      (Xu et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dronc2
      Nc2
      dronc2
      (Verghese et al., 2012, Minakhina et al., 2007, Minakhina and Steward, 2006, Xu et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)