FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DJ-1αUAS.cYa
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General Information
Symbol
Dmel\DJ-1αUAS.cYa
Species
D. melanogaster
Name
FlyBase ID
FBal0191186
Feature type
allele
Associated gene
Dmel\DJ-1α
Associated Insertion(s)
Carried in Construct
P{UAS-DJ-1α}
Also Known As
UAS-DJ-1A
Key Links
Transgenic product class
wild_type
(Yang et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yang et al., 2005)
Mutagen
in vitro construct
(Yang, 2005, Yang et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-DJ-1α}
Cytology
Description

UASt regulatory sequences drive expression of DJ-1α coding sequences.

(Yang et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
DJ-1α
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DJ-1αdsRNA.Scer\UAS (under the control of Scer\GAL4elav-C155) flies are more sensitive to 3-AT (a known inhibitor of catalase, which converts H2O2 to H20) exposure compared to control flies.

      (Yang et al., 2005)

      Overexpression of DJ-1αScer\UAS.cYa ubiquitously, under the control of Scer\GAL4da.G32 leads to resistance against H2O2 stress and 3-AT treatment (a known inhibitor of catalase, which converts H2O2 to H20).

      (Yang, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      DJ-1αUAS.cYa/Scer\GAL4GMR.PF partially rescues DJ-1αRNAi.UAS

      (Yang et al., 2005)
      Comments

      Expression of a DJ-1αScer\UAS.cYa transgene partially rescues the DJ-1αdsRNA.Scer\UAS (Scer\GAL4GMR.PF) eye degeneration phenotype.

      (Yang et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DJ-1αScer\UAS.cYa
      DJ-1αUAS.cYa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)