FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ercc1X
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General Information
Symbol
Dmel\Ercc1X
Species
D. melanogaster
Name
FlyBase ID
FBal0191200
Feature type
allele
Associated gene
Dmel\Ercc1
Associated Insertion(s)
TI{TI}Ercc1X
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
I-CreI
(Radford et al., 2005)
gene targeting by homologous recombination
(Radford et al., 2005)
Progenitor genotype
Ercc1Xdup
(Radford et al., 2005)
Associated Insertion(s)
TI{TI}Ercc1X
Cytology
Description

Imperfect reduction of the duplication present in Dp(3;3)Ercc1Xdup, using I-CreI endonuclease. The structure around the mutation site is as follows: SMC2, mutated copy of Ercc1, wild-type copy of Ciao1, 1218bp of extra sequence from the original homologous recombination donor template (which contains a 5' portion of HPS1, the FRT site, the RS(I-CreI) site and a portion of the w gene), HPS1.

(Radford et al., 2005)
Allele components
Component
Use(s)
Also carries
FRT
RS(I-CreI)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and Ercc1X/Df(2R)knSA3 larvae are hypersensitive to UV light compared to wild-type. Mutants are also hypersensitive to methyl methanesulfonate. Zygotic Ercc1X mutants show 16% X chromosome nondisjunction and have a reduction in crossing over along the 3rd chromosome. Ercc1X mutants derived from Ercc1X females show 23% X chromosome nondisjunction and have a reduction in crossing over along the 3rd chromosome.

      (Radford et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Ercc1X has abnormal meiotic cell cycle phenotype, enhanceable by pch2EY01788a

      (Joyce and McKim, 2010)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Ercc1X has phenotype, non-suppressible by mei-9Ubi.Tag:FLAG

      (Radford et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The level of X chromosome nondisjunction seen in Ercc1X mutants derived from Ercc1X females is not altered if the flies are also carrying mei-9Ubi.T:Zzzz\FLAG.

      (Radford et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Recovered in trans to Df(2R)knSA3.

      (Radford et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ercc1X
      (Joyce and McKim, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)