FB2026_02 , released June 18, 2026
Allele: Dmel\pch2EY01788a
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General Information
Symbol
Dmel\pch2EY01788a
Species
D. melanogaster
Name
FlyBase ID
FBal0157070
Feature type
allele
Associated gene
Dmel\pch2
Associated Insertion(s)
P{?EPgy2}pch2EY01788a
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{?EPgy2}pch2EY01788a
Cytology
Description

Insertion of a 473bp partially deleted P{EPgy2} element towards the end of the first exon. This insertion results in a frameshift early in the protein.

(Joyce and McKim, 2009)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pch2EY01788a/Df(3R)p-XT103 females show a normal distribution and frequency of X-chromosome crossing over.

      The frequency of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining) in pch2EY01788a females is not significantly different from that seen in wild-type females.

      (Joyce and McKim, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      pch2EY01788a is an enhancer of abnormal meiotic cell cycle phenotype of Ercc1X

      (Joyce and McKim, 2010)
      Suppressor of
      Statement
      Reference

      pch2EY01788a is a suppressor of abnormal meiotic cell cycle phenotype of mei-9a

      (Joyce and McKim, 2010)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pch2EY01788a/pch2EY01788a suppresses the defect in oocyte commitment (high frequency of 'two-oocyte phenotype' in region 3 of the germarium) that is seen in polo1/poloS025604 germaria.

      (Pek et al., 2012)

      The high frequency of region 3 cysts containing two pro-oocytes that is seen in hdmg7, mei-9A2 or okrWS homozygous females is suppressed by pch2EY01788a.

      pch2EY01788a enhances the increased X chromosome non-disjunction phenotype seen in hdmg7 females.

      (Joyce and McKim, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: P{EPgy2}EY01788b.

      (Joyce and McKim, 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG31453EY01788a
      pch2EY01788a
      (Pek et al., 2012, Joyce and McKim, 2010)
      pch2EY
      (Joyce and McKim, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)