FB2026_02 , released June 18, 2026
Allele: Dmel\Cap-G64
Open Close
General Information
Symbol
Dmel\Cap-G64
Species
D. melanogaster
Name
FlyBase ID
FBal0191513
Feature type
allele
Associated gene
Dmel\Cap-G
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: D254Y. Nucleotide substitution: G954T. The above mutation affects a conserved residue within a predicted HEAT repeat.

    (Cobbe et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:13,134,219..13,134,219 [+]
    Nucleotide change:

    G13134219T

    Reported nucleotide change:

    G954T

    Amino acid change:

    D254Y | Cap-G-PF; D254Y | Cap-G-PG

    Reported amino acid change:

    D254Y

    (Cobbe et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cap-G64 homozygous and Cap-G6/Cap-G64 embryos often show severe but variable defects, which range from embryos with reduced, mis-arranged musculature and missing or duplicated heart cells to embryos of aberrant shape without recognizable musculature.

        (Jacobs, 2018.7.9)

        Cap-G64 mitotic cells accumulate in prophase/premetaphase. These cells delay in metaphase and display a high frequency of anaphase and telophase bridges.

        (Cobbe et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Statement
        Reference

        Cap-G64 has enhancer of variegation phenotype, non-suppressible by glu88-82

        (Cobbe et al., 2006)
        NOT Suppressor of
        Statement
        Reference

        Cap-G64 is a non-suppressor of suppressor of variegation phenotype of In(1)wm4, glu88-82

        (Cobbe et al., 2006)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Intermediate eye pigment levels are observed in glu88-82, Cap-G64 double mutants with a In(1)wm4h background, showing that glu88-82 suppressor effects of PEV are not dominant over the enhancer activity of Cap-G64.

        (Cobbe et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Cap-G64
        dcap-g64
        (Cobbe et al., 2006)
        red sea64
        (Cobbe et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)