FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SMC2jsl2
Open Close
General Information
Symbol
Dmel\SMC2jsl2
Species
D. melanogaster
Name
FlyBase ID
FBal0191670
Feature type
allele
Associated gene
Dmel\SMC2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Cobbe et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?827term.

(Cobbe et al., 2006)

The premature stop codon should result in production of a truncated SMC2 protein which lacks the C-terminal globular domain and part of the adjacent coiled-coil sequence.

(Cobbe et al., 2006)

Nucleotide substitution: C2482T.

(Cobbe et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:14,849,730..14,849,730 [-]
Nucleotide change:

C14849730T

Reported nucleotide change:

C2482T

Amino acid change:

Q828term | SMC2-PA

Reported amino acid change:

?827term

Comment:

The mutation is reported as a C to T nucleotide change in codon 827 leading to a nonsense mutation. A C to T change in codon 827 (Leu - CTG) does not result in a stop codon but a C to T change in the adjacent Gln (CAG) codon would result in a premature stop.

(Cobbe et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval brain

      (Cobbe et al., 2006)

      mitosis & nuclear chromosome

      (Cobbe et al., 2006)
      Detailed Description
      Statement
      Reference

      The brains of SMC2jsl2 third instar larvae are much smaller than wild-type brains. The brains of SMC2jsl2 second instar larvae show a much lower percentage of mitotic cells than wild type. The chromosomes of these cells appear fuzzy with almost no sister chromatid resolution. All telophase and anaphase-like cells show chromatin bridges and an abnormally high percentage of anaphase cells also show bridges. However, there are no obvious delays in mitotic progression.

      (Cobbe et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      J. Sekelsky

      (Cobbe et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SMC2jsl2
      (Hasan et al., 2024, Christensen et al., 2008.4.15)
      smc2jsl2
      (Cobbe et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)