FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mps1GS13084
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General Information
Symbol
Dmel\Mps1GS13084
Species
D. melanogaster
Name
FlyBase ID
FBal0191993
Feature type
allele
Associated gene
Dmel\Mps1
Associated Insertion(s)
P{GSV6}Mps1GS13084
Carried in Construct
Also Known As
P{GS:13084}
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gilliland et al., 2005)
Mutagen
P-element activity
(Gilliland et al., 2005)
Progenitor genotype
Associated Insertion(s)
P{GSV6}Mps1GS13084
Cytology
Description

Insertion of a P{GSV6} element at nucleotide 15 of the 5' UTR of ald.

(Gilliland et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{GSV6}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      meiosis & nuclear chromosome

      (Gilliland et al., 2005)

      meiosis & nuclear chromosome (with Df(3R)ED5780)

      (Gilliland et al., 2005)
      Detailed Description
      Statement
      Reference

      aldGS13084 mutants show segregational defects for achiasmate homologs. The frequency of achiasmate X chromosome nondisjunction is increased more than 15-fold in FM7a/X; aldGS13084 females, compared to controls. The frequency of nondisjunction is even greater (>65-fold higher than controls) in FM7a/X; aldGS13084/Df(3R)ED5780 females and these mutants also show a ~10% frequency of chiasmate X chromosome nondisjunction. Both FM7a/X; aldGS13084 and FM7a/X; aldGS13084/Df(3R)ED5780 mutants show increased levles of achiasmate 4th chromosome nondisjunction. ald1 neuroblasts exhibit a failure of the meiotic spindle checkpoint. Following treatment with colchicine, the checkpoint of wild-type neuroblasts is activated and cell arrest in metaphase. In contrast, almost 35% of aldGS13084 neuroblasts and ~7.5% of aldGS13084/+ neuroblasts fail to arrest, as shown by precocious chromatid separation.

      (Gilliland et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Mps1ald-1

      (Gilliland et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from a lethal mutation on the chromosome; precise excision of the P{GSV6}aldGS13084 element does not rescue lethality.

      (Gilliland et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mps1GS13084
      aldGS13084
      Name Synonyms
      Secondary FlyBase IDs
        References (2)