FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-278KO
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General Information
Symbol
Dmel\mir-278KO
Species
D. melanogaster
Name
FlyBase ID
FBal0192080
Feature type
allele
Associated gene
Dmel\mir-278
Associated Insertion(s)
TI{TI}mir-278KO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)
Mutagen
FLPase
(Teleman and Cohen, 2006)
I-SceI
(Teleman and Cohen, 2006)
recombination
(Teleman and Cohen, 2006)
ends-out gene targeting
(Teleman and Cohen, 2006)
Progenitor genotype
Associated Insertion(s)
TI{TI}mir-278KO
Cytology
Description

Knock-out of the mir-278 gene. It is not known whether or not expression of the host CG42524 gene is affected.

(Chen et al., 2014)

160bp of genomic sequence, including the mir-278 hairpin, has been replaced by a w+* marker.

(Teleman and Cohen, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos show a significant decrease in primordial germ cell number compared to controls.

      Homozygous adults show significant defects in the hemolymph-brain barrier (as determined using a dye injection assay).

      mir-278KO/Df(2R)BSC427 animals show a significant increase in viability compared to controls.

      (Chen et al., 2014)

      Homozygous mutant germline stem cells in the ovary show a 25% reduction in division index compared to control clones.

      Germline stem cells in mir-278KO/mir-278Gal4KI females show a 28% reduction in the number of cystoblasts and cysts at region 1-2A in germaria as compared with heterozygous controls 13-14 days after eclosion.

      (Yu et al., 2009)

      Homozygotes have a normal body size. Homozygous adults are lean, measured as the normalised ratio of total body triglycerides to total protein, with the magnitude of the difference increasing during the first few days of adult life. mir-278KO/mir-278Gal4KI adults are also lean. Mutants have elevated levels of circulating trehalose.

      (Teleman and Cohen, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      mir-278KO is a suppressor of partially lethal phenotype of chicounspecified

      (Teleman and Cohen, 2006)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      mir-278KO has phenotype, suppressible by Pi3K92Eunspecified/Pi3K92E[+]

      (Teleman and Cohen, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The leanness of mir-278KO homozygotes is largely suppressed by Pi3K92Eunspecified/+.

      (Teleman and Cohen, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      miR-278KO
      (Yu et al., 2009)
      mir-278KO
      (Niu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)