FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-278Gal4KI
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General Information
Symbol
Dmel\mir-278Gal4KI
Species
D. melanogaster
Name
FlyBase ID
FBal0191034
Feature type
allele
Associated gene
Dmel\mir-278
Associated Insertion(s)
TI{GAL4}mir-278Gal4KI
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Teleman and Cohen, 2006)
Mutagen
FLPase
(Teleman and Cohen, 2006)
I-SceI
(Teleman and Cohen, 2006)
recombination
(Teleman and Cohen, 2006)
ends-out gene targeting
(Teleman and Cohen, 2006)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}mir-278Gal4KI
Cytology
Description

160bp of the mir-278 locus, including the mir-278 hairpin, have been replaced by sequence encoding a w+* marker and a GAL4 driver. This results in the GAL4 coding sequence being under the control of mir-278 regulatory sequences.

(Teleman and Cohen, 2006)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutant germline stem cells in the ovary show a 21% reduction in division index compared to control clones.

      Germline stem cells in mir-278KO/mir-278Gal4KI females show a 28% reduction in the number of cystoblasts and cysts at region 1-2A in germaria as compared with heterozygous controls 13-14 days after eclosion.

      (Yu et al., 2009)

      Homozygotes have a normal body size. mir-278KO/mir-278Gal4KI adults are lean, measured as the normalised ratio of total body triglycerides to total protein.

      (Teleman and Cohen, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gal4KI
      (Teleman and Cohen, 2006)
      mir-278Gal4KI
      (Yu et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)