FB2026_02 , released June 18, 2026
Allele: Dmel\TkEY20174
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General Information
Symbol
Dmel\TkEY20174
Species
D. melanogaster
Name
FlyBase ID
FBal0192550
Feature type
allele
Associated gene
Dmel\Tk
Associated Insertion(s)
P{EPgy2}TkEY20174
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Im et al., 2015)
Mutagen
P-element activity
(Bellen, 2006.8.3)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}TkEY20174
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TkEY20174/TkEY20174 or TkEY20174/TkΔ1C early third instar larvae do not have significantly different baseline thermal nociception (uninjured larval responses to thermal probes at 45[o] or 48[o]C) compared to controls. 24 hours after UV-induced nociceptive sensitization, early third instar TkEY20174/TkEY20174, TkEY20174/TkΔ1C or TkEY20174/Df(3R)Exel7312 larvae show significant reduction of thermal allodynia (withdrawal responses to a sub-threshold 38[o]C probe) compared to wild type or heterozygote larvae.

      (Im et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TkEY20174
      (Bellen, 2006.8.3)
      dTkEY21074
      (Im et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)