FlyBase Allele Report: Dmel\Tk[Δ1C]

General Information

Symbol

Dmel\Tk^Δ1C

Species

D. melanogaster

Name

FlyBase ID

FBal0318686

Feature type

allele

Associated gene

Dmel\Tk

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Im et al., 2015)

Mutagen

FLPase

(Im et al., 2015)

Progenitor genotype

PBac{WH}Tk^f03824

(Im et al., 2015)

P{XP}d08303

(Im et al., 2015)

Cytology

Description

Deletion that removes most of the Tk gene. Generated by FLP-mediated recombination between the P{XP}d08303 and PBac{WH}Tk^f03824 insertions.

(Im et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | early third instar larval stage | conditional (with Df(3R)Exel7312)

(Im et al., 2015)

abnormal pain response | early third instar larval stage | conditional (with Tk^EY20174)

(Im et al., 2015)

abnormal pain response | early third instar larval stage | recessive | conditional

(Im et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Tk^Δ1C/Tk^Δ1C or Tk^EY20174/Tk^Δ1C early third instar larvae do not have significantly different baseline thermal nociception (uninjured larval responses to thermal probes at 45[o] or 48[o]C) compared to controls. 24 hours after UV-induced nociceptive sensitization, early third instar Tk^Δ1C/Tk^Δ1C, Tk^EY20174/Tk^Δ1C or Tk^Δ1C/Df(3R)Exel7312 larvae show significant reduction of thermal allodynia (withdrawal responses to a sub-threshold 38[o]C probe) compared to wild type or heterozygote larvae.

(Im et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Tk^Δ1C, smo[+]/smo³ has abnormal pain response | early third instar larval stage | conditional phenotype

(Im et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

24 hours after UV-induced nociceptive sensitization, early third instar smo³/+;Tk^Δ1C/+ larvae show a significant reduction of thermal allodynia (withdrawal responses to a sub-threshold 38[o]C probe) compared to heterozygotic smo³/+ or Tk^Δ1C/+ larvae.

(Im et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tk^Δ1C

dTk^Δ1C

(Im et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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