FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF4EHPCP53
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General Information
Symbol
Dmel\eIF4EHPCP53
Species
D. melanogaster
Name
FlyBase ID
FBal0192974
Feature type
allele
Associated gene
Dmel\eIF4EHP
Associated Insertion(s)
Carried in Construct
Also Known As
d4EHPCP53, 4EHPCP53
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cho et al., 2005)
Mutagen
P-element activity
(Cho et al., 2005)
Progenitor genotype
eIF4EHPBG01713
(Cho et al., 2005)
Cytology
Description

Imprecise excision of P{GT1}4EHPBG01713 has caused the deletion of approximately 2.1kb - including all of exon 1 of 4EHP and part of intron 1.

(Cho et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos produced by homozygous d4EHPCP53 females have a substantially reduced hatching frequency (52%) compared to wild-type flies (93%). Flies that do hatch have no conspicuous phenotypic defects, even when genetically homozygous themselves. The embryos that do not hatch exhibit patterning defects mostly affecting anterior segmentation.

      (Cho et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Some protein is made from this mutant gene, probably due to translational initiation at a second AUG near the end of intron 1 (the mutation deletes the primary AUG). The predicted product lacks the first 12 amino acids, which are replaced with 6 new ones.

      (Cho et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      4EHPCP53
      (Walsh et al., 2025, Tadros et al., 2007)
      d4EHPCP53
      (Olesnicky et al., 2012, Cho et al., 2006, Cho et al., 2005)
      d4EHPcp53
      (Singh et al., 2011)
      eIF4EHPCP53
      Name Synonyms
      Secondary FlyBase IDs
        References (6)