FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Six4UAS.cCa
Open Close
General Information
Symbol
Dmel\Six4UAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0193495
Feature type
allele
Associated gene
Dmel\Six4
Associated Insertion(s)
Carried in Construct
P{UAS-Six4.C}
Key Links
Transgenic product class
wild_type
(Clark et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Clark et al., 2006)
Mutagen
in vitro construct
(Clark et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Six4.C}
Cytology
Description

UASt regulatory sequences drive expression of the Six4 ORF.

(Clark et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Six4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4GMR.PU-mediated expression of Six4Scer\UAS.cCa moderately inhibits eye development.

      (Weasner and Kumar, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4ey.PU-mediated expression of Six4Scer\UAS.cCa significantly rescues the so1 eye phenotype.

      (Weasner and Kumar, 2009)

      Co-expression of eyaScer\UAS.cBa and Six4Scer\UAS.cCa in the twi domain, under the control of Scer\GAL4twi.PG strongly affects the mesoderm. Several cell types derived from the ventral and dorsolateral mesoderm expand. Greatly increased numbers of somatic gonadal precursors results in an enlarged gonad. There are also more fat body precursors, and these now extend into the dorsal region of the mesoderm, suggesting that dorsal cells have taken on more ventral fates. In contrast, derivatives of the dorsal mesoderm are disrupted. In stage 17 embryos no myosin-expressing cardioblasts are visible, while there are gaps in the pattern of dorsal muscles. Similarly, there are gaps in the visceral mesoderm at stage 12. In the ventral region of the somatic musculature, there are duplications of the ventral acute muscle (VA3), while the pattern of ventral oblique muscles is disrupted. The lateral somatic musculature also appears larger.

      (Clark et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Six4Scer\UAS.cCa
      Six4UAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)