FlyBase Allele Report: Dmel\cic[BA53]

General Information

Symbol

Dmel\cic^BA53

Species

D. melanogaster

Name

FlyBase ID

FBal0193543

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C2563T.

(Atkey et al., 2006)

The base pair transition from C to T at position 2563 of the genomic sequence introduces a stop codon near the end of the third exon.

(Atkey et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage (with cic^fet-U6)

(Atkey et al., 2006)

egg (with cic^fet-U6)

(Atkey et al., 2006)

Detailed Description

Statement

Reference

Approximately 14.1% of cic^fet-U6/cic^BA53 exhibit a moderate-severe eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a pronounced ventral collar of ectopic appendage-like material. The dorsalmost region remains free of appendage material.

Approximately 85.9% of cic^fet-U6/cic^BA53 exhibit a severe eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a pronounced ventral collar of ectopic appendage-like material, along with small anterior projections.

(Atkey et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

cic^fet-U6/cic^BA53 has dorsal appendage phenotype, suppressible by mirr^6D1

(Atkey et al., 2006)

cic^fet-U6/cic^BA53 has egg phenotype, suppressible by mirr^6D1

(Atkey et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 0.5% of cic^fet-U6/mirr^6D1 cic^BA53 females exhibit a moderate eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a ventral collar of ectopic appendage-like material. The dorsalmost region remains free of appendage material. Approximately 32.6% of cic^fet-U6/mirr^6D1 cic^BA53 females exhibit a severe eggshell phenotype (compared to 85.9 in the heterozygote). The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a pronounced ventral collar of ectopic appendage-like material, along with small anterior projections.There is an increase in the weak phenotype, and a decrease in the severe phenotype compared to the cic^BA53/cic^fet-U6 mutant, indicating that mirr^6D1 suppresses the cic^BA53/cic^fet-U6 phenotype.

(Atkey et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cic^BA53

(Atkey et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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