FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tsr110M
Open Close
General Information
Symbol
Dmel\tsr110M
Species
D. melanogaster
Name
FlyBase ID
FBal0193698
Feature type
allele
Associated gene
Dmel\tsr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Janody and Treisman, 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: G67E.

(Janody and Treisman, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,044,914..24,044,914 [-]
Nucleotide change:

G24044914A

Amino acid change:

G67E | tsr-PA

Reported amino acid change:

G67E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Janody and Treisman, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tsr110M mutant clones within mosaic third instar larval wing discs are significantly smaller than control clones; these clones show a small increase in apoptosis (Casp3 immunofluorescence), as compared to controls.

      (Ko et al., 2016)

      tsr110M mutant clones survive equally well in all regions of the wing disc.

      (Janody and Treisman, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tsrk05633

      (Janody and Treisman, 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tsr110M
      (Ko et al., 2016, Fernández et al., 2011, Janody and Treisman, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)