FB2026_02 , released June 18, 2026
Allele: Dmel\Gr63aUAS.cJa
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General Information
Symbol
Dmel\Gr63aUAS.cJa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Jones
FlyBase ID
FBal0193766
Feature type
allele
Associated gene
Dmel\Gr63a
Associated Insertion(s)
Carried in Construct
P{UAS-Gr63a.J}
Also Known As
UAS-Gr63a
Key Links
Transgenic product class
wild_type
(Jones et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Jones et al., 2007)
Mutagen
in vitro construct
(Jones et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Gr63a.J}
Cytology
Description

UAS regulatory sequences drive expression of Gr63a.

(Jones et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gr63a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Female flies expressing Gr63aScer\UAS.cJa driven by Scer\GAL4Gr63a.PF have a similar lifespan to controls.

      Female flies expressing Gr63aScer\UAS.cJa under control of the Scer\GAL4Gr63a.PF driver show similar triglyceride levels to controls.

      (Poon et al., 2010)

      Expression of Gr63aScer\UAS.cJa under the control of Scer\GAL4Or22a.7.717 does not confer CO2 responsiveness onto ab3A neurons.

      (Jones et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of both Gr63aScer\UAS.cJa and Gr21aScer\UAS.cJa under the control of Scer\GAL4Ir64a.PA in Ir64aMB05283, Gr63a1 double mutant flies allows artificial stimulation of DC4 dorsal glomeruli of the adult antennal lobe by 5% CO[[2]] and robust avoidance of CO[[2]] in behavioural experiments. However, DP1m neurons are not activated by CO[[2]] in these mutants.

      (Ai et al., 2010)

      Coexpression of Gr21aScer\UAS.cJa and Gr63aScer\UAS.cJa under the control of Scer\GAL4Or22a.7.717 confers CO2 responsiveness on ab3A neurons, a type of neuron that is normally unresponsive to CO2. This is in contrast to expression of either UAS transgene alone or in combination with Gr10aScer\UAS.cJa, where CO2 responsiveness is not conferred. Coexpression of Gr21aScer\UAS.cJa and Gr63aScer\UAS.cJa also increases the level of spontaneous activity in the ab3A neuron. Coexpression of Gr21aScer\UAS.cJa and Gr63aScer\UAS.cJa also increases the level of spontaneous activity in the ab3A neuron.

      (Jones et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Gr63aUAS.cJa/Scer\GAL4Gr63a.PF rescues Gr63a1

      (Poon et al., 2010)
      Partially rescues

      Scer\GAL4Gr21a.9.323/Gr63aUAS.cJa partially rescues Gr63a1

      (Jones et al., 2007)
      Comments

      Expression of Gr63aScer\UAS.cJa under the control of the native promoter (Scer\GAL4[Gr63a.PF]) restores the increased lifespan phenotype of Gr63a1 females to wild type levels.

      Expression of Gr63aScer\UAS.cJa under the control of the Scer\GAL4Gr63a.PF driver rescues the high triglyceride level phenotype seen in Gr63a1 female mutants.

      (Poon et al., 2010)

      Expression of Gr63aScer\UAS.cJa under the control of Scer\GAL4Gr21a.9.323 rescues the ability of ab1C neurons to respond to CO2 in Gr63a1 flies and partially rescues the ability of Gr63a1 flies to avoid CO2 in a T-maze.

      (Jones et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gr63aScer\UAS.cJa
      Gr63aUAS.cJa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Jones
      Secondary FlyBase IDs
        References (4)