FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GripΔ1-3.UAS
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General Information
Symbol
Dmel\GripΔ1-3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0194044
Feature type
allele
Associated gene
Dmel\Grip
Associated Insertion(s)
Carried in Construct
P{UAS-Grip.Δ1-3}
Key Links
Transgenic product class
inframe_deletion
(Swan et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Swan et al., 2006)
Mutagen
in vitro construct
(Swan et al., 2006, Swan et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Grip.Δ1-3}
Cytology
Description

UAS regulatory sequences drive expression of a deleted form of Grip (corresponding to RE14068) which is missing amino acid residues 83-378.

(Swan et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Grip
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      lateral transverse muscle cell, with Gripex36, Scer\GAL4twi.PG

      (Swan et al., 2006)

      lateral transverse muscle cell, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 1 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 1 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 2 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 2 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 3 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 3 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 4 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 4 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 5 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 5 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 6 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 6 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      muscle cell of abdominal 7 dorsal oblique muscle 5, with Scer\GAL4slou.S59

      (Swan et al., 2006)

      muscle cell of abdominal 7 dorsal oblique muscle 5, with Scer\GAL4twi.PG

      (Swan et al., 2006)

      ventral longitudinal muscle cell, with Gripex36, Scer\GAL4twi.PG

      (Swan et al., 2006)
      Detailed Description
      Statement
      Reference

      Expression of GripΔ1-3.Scer\UAS, under the control of Scer\GAL4twi.PG leads to very strong defects in lateral transverse muscles (LTMs) in wild-type, Gripex36 and Gripex36/+ backgrounds. LTM defects include splitting into multiple projections, bending away from their target tendon cells and forming aberrant, integrin positive attachments in ectopic positions. These defects appear qualitatively very similar when scored in embryos or in larvae. Scer\GAL4twi.PG>GripΔ1-3.Scer\UAS expression in a Gripex36 or Gripex36/+ background results in slight ventrolateral muscleventrolateral muscle (VLM) defects.

      Expression of GripΔ1-3.Scer\UAS in muscle 5, driven by Scer\GAL4slou.S59, results in formation of extra filopodia-like projections not present in wild-type muscle 5. These additional projections are still obvious in larval stages and other muscles can ectopically adhere to the GripΔ1-3.Scer\UAS-expressing muscles.

      (Swan et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      GripΔ1-3.UAS, Scer\GAL4twi.PG has lateral transverse muscle cell phenotype, suppressible by edslH8

      (Swan et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of GripΔ1-3.Scer\UAS, under the control of Scer\GAL4twi.PG in a edslH8 background causes a mild lateral transverse muscle phenotype similar to that seen in edslH8 embryos without transgene expression. This is in contrast to the more severe phenotype seen when GripΔ1-3.Scer\UAS is expressed in a wild-type background.

      (Swan et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4twi.PG/GripΔ1-3.UAS partially rescues Gripex36

      (Swan et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GripΔ1-3.Scer\UAS
      GripΔ1-3.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)