FlyBase Allele Report: Dmel\Traf4[ex1]

General Information

Symbol

Dmel\Traf4^ex1

Species

D. melanogaster

Name

FlyBase ID

FBal0194140

Feature type

allele

Associated gene

Dmel\Traf4

Associated Insertion(s)

Carried in Construct

Also Known As

DTRAF1^ex1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cha et al., 2003)

Mutagen

Delta2-3 transposase

(Cha et al., 2003)

Progenitor genotype

Traf4^EP578

(Cha et al., 2003)

Cytology

Description

The upstream Traf4 promoter is deleted in Traf4^ex1 mutants, while the downstream promoter is intact.

(Mathew et al., 2009)

Imprecise excision of the P{EP} element, resulting in deletion of a 2.8kb region starting from the point of the original insertion.

(Cha et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinitis pigmentosa

modeled by ninaE^P37H, ninaE¹⁷

(Griciuc et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | larval stage

(Cha et al., 2003)

lethal - all die before end of larval stage

(Cha et al., 2003)

some die during larval stage

(Cha et al., 2003)

Phenotype Manifest In

eye disc

(Cha et al., 2003)

eye photoreceptor cell & axon

(Cha et al., 2003)

imaginal disc

(Cha et al., 2003)

Detailed Description

Statement

Reference

Homozygous Traf4^ex1 mutant embryos appear normal.

(Mathew et al., 2009)

Traf1^ex1 larvae contain small imaginal discs; the eye disc is especially small. Photoreceptor axons in Traf1^ex1 larvae form few axonal bundles and fail to defasciculate the brain hemisphere. The brain-ventral ganglia complex shows no apparent defects.

(Cha et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Traf4[+]/Traf4^ex1 is a suppressor of abnormal neurophysiology phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

Traf4[+]/Traf4^ex1 is a suppressor of abnormal neuroanatomy phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

NOT Suppressor of

Statement

Reference

Traf4[+]/Traf4^ex1 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Traf1[+]/Traf4^ex1 is an enhancer of thorax phenotype of Scer\GAL4^ap-md544, bsk^DN.UAS

(Cha et al., 2003)

Suppressor of

Statement

Reference

Traf4[+]/Traf4^ex1 is a suppressor of rhabdomere of eye photoreceptor cell phenotype of ninaE¹⁷, ninaE^P37H

(Griciuc et al., 2014)

NOT Suppressor of

Statement

Reference

Traf4[+]/Traf4^ex1 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Retinal degeneration and light-response defects are strongly suppressed in ninaE^P37H, ninaE¹⁷, Traf4^ex1/+ flies.

(Griciuc et al., 2014)

The small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF is not suppressed by Traf4^ex1/+.

(Xue et al., 2007)

Expression of bsk^DN.Scer\UAS, under the control of Scer\GAL4^ap-md544, in a Traf1^ex1/+ background results in an enhancement of the thorax closure defect seen in Scer\GAL4^ap-md544>bsk^DN.Scer\UAS flies. The Scer\GAL4^ap-md544>bsk^DN.Scer\UAS, Traf1^ex1 flies have a larger cleft and the notum structure is disrupted.

(Cha et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Traf4^ex1 is viable over deficiencies that remove Traf4 indicating that the lethality associated with Traf4 may not be due to the Traf4 locus.

(Mathew et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

DTRAF1^ex1

(Griciuc et al., 2014, Cha et al., 2003)

DTRAF1^ex

(Xue et al., 2007)

Traf1^LOF

(Griciuc et al., 2014)

Traf1^ex1

Traf4^ex1

(Zhu et al., 2019, Mathew et al., 2011, Mathew et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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