FlyBase Allele Report: Dmel\Debcl[GS2263]

General Information

Symbol

Dmel\Debcl^GS2263

Species

D. melanogaster

Name

FlyBase ID

FBal0194704

Feature type

allele

Associated gene

Dmel\Debcl

Associated Insertion(s)

P{GSV1}Debcl^GS2263

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Senoo-Matsuda et al., 2005)

Progenitor genotype

Associated Insertion(s)

P{GSV1}Debcl^GS2263

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GSV1}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:6,648,621..6,648,621

(Senoo-Matsuda et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived, with Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of debcl^GS2263, under the control of Scer\GAL4^elav-C155, extends lifespan slightly (78.3 days vs. 72.3 days in controls).

Ectopic expression of debcl^GS2263 at moderate levels, under the control of Scer\GAL4^GMR.PF, causes no detectable phenotype in the eye.

(Senoo-Matsuda et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Debcl^GS2263, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Debcl^GS2263, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Debcl^GS2263, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Debcl^GS2263, Scer\GAL4^GMR.PF is a suppressor of pigment granule phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Ectopic expression of debcl^GS2263, under the control of Scer\GAL4^GMR.PF, suppresses the Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}-induced neurodegeneration of the eye. In addition, debcl^GS2263 markedly rescues the early adult death of flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} in their neurons, driven by Scer\GAL4^elav-C155.

(Senoo-Matsuda et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

200372

y¹ w^67c23; P{GSV1}Debcl^GS2263/SM1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Debcl^GS2263

debcl^GS2263

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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