Drob-1, dBorg-1, Bcl-2, dBorg1, BOK
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Debcl using the Feature Mapper tool.
RT-PCR analysis indicates that Debcl transcripts are expressed at all stages of development. In situ hybridization reveals that Debcl transcripts are expressed at high levels in early embryos. Expression is also observed in third instar larvae in leg, wing, and eye disc and in the midgut.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Debcl in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Debcl debcl
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
debcl protects neurons from neurodegeneration through the regulation of mitochondrial homeostasis.
dsRNA made from templates generated with primers directed against this gene causes a phenotype in S2 cells. The reduced mitochondrial membrane potential and increase in cell death caused by treatment of cells with rotenone or 3-NP is enhanced. Cell death induction by treatment with proteasome inhibitors is likewise enhanced, while cell death induction by tunicamycin is not affected. Additionally, debcl knockdown significantly increases the percentage of mitochondria showing abnormal morphologies in S2 cells with intact nuclei and enhances the reduction of activities of mitochondrial respiratory chain complex I +III (NADH-cytochrome c oxidoreductase) and complex II +III (succinate-cytochrome c oxidoreductase) in S2 cells treated with rotenone or 3-NP.
Area matching Drosophila ESTs AI062455 and AA440915.
debcl both induces apoptosis and demonstrates protective activity when death stimuli are introduced.