FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Debcl
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General Information
Symbol
Dmel\Debcl
Species
D. melanogaster
Name
Death executioner Bcl-2
Annotation Symbol
CG33134
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029131
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Drob-1, Bcl-2, dBorg-1, dBorg1, BOK

Key Links
Genomic Location
Cytogenetic map
42B2-42C1
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:6648654..6652842
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000135648
(GO Reference Genome Project, 2011-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in apoptotic process involved in morphogenesis
inferred from mutant phenotype
(Colussi et al., 2000)
involved_in apoptotic process
inferred from mutant phenotype
(Brachmann et al., 2000)
inferred from genetic interaction with FLYBASE:Diap1; FB:FBgn0260635
(Colussi et al., 2000)
inferred from genetic interaction with FLYBASE:Dark; FB:FBgn0263864
(Colussi et al., 2000)
involved_in cellular response to starvation
inferred from mutant phenotype
(Hou et al., 2008)
involved_in ectopic germ cell programmed cell death
inferred from mutant phenotype
(Yacobi-Sharon et al., 2013)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage
inferred from mutant phenotype
(Brachmann et al., 2000)
involved_in negative regulation of neuron apoptotic process
inferred from mutant phenotype
(Senoo-Matsuda et al., 2005)
involved_in neuron cellular homeostasis
inferred from genetic interaction with FLYBASE:Ank2; FB:FBgn0261788
(Keller et al., 2011)
involved_in positive regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
involved_in positive regulation of programmed necrotic cell death
inferred from mutant phenotype
(Napoletano et al., 2017)
involved_in programmed cell death involved in cell development
inferred from mutant phenotype
(Galindo et al., 2009)
involved_in regulation of programmed cell death
inferred from genetic interaction with FLYBASE:Dark; FB:FBgn0263864
(Galindo et al., 2009)
involved_in response to ionizing radiation
inferred from mutant phenotype
(Galindo et al., 2009)
NOT involved_in autophagy
inferred from mutant phenotype
(Galindo et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from sequence or structural similarity with UniProtKB:P10415
(Igaki et al., 2000)
involved_in regulation of apoptotic process
inferred from electronic annotation with InterPro:IPR026298, InterPro:IPR036834
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of Bcl-2 family protein complex
inferred from physical interaction with FLYBASE:synr; FB:FBgn0031650,FLYBASE:Buffy; FB:FBgn0040491
(Ikegawa et al., 2023)
located_in mitochondrial envelope
inferred from direct assay
(Igaki et al., 2000)
located_in mitochondrion
inferred from direct assay
(Doumanis et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrial outer membrane
inferred from biological aspect of ancestor with PANTHER:PTN000135648
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
BCL-2 FAMILY -
The BCL-2 family are proteins that share up to four different BCL-2 homology (BH) motifs (BH1-BH4) within an alpha-helical bundle domain. Bcl-2 proteins can have pro- or anti-apoptotic activities. (Adapted from FBrf0187831 & PMID:26541461.)
Summary (Interactive Fly)

Bcl-2/CED-9 family protein involved in regulating apoptosis - Screening of suppressors of bax-induced cell death identifies Glycerophosphate oxidase-1 as a mediator of Debcl-induced apoptosis

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Debcl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V9C8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Debcl-RA
FBtr0086108
NM_176098
1724
300
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

(Colussi et al., 2000)

1.3 (northern blot)

(Igaki et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Debcl-PA
FBpp0085443
32.9
300
9.53
Q9V9C8
NP_788278
AAF57365
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

300 (aa); 33 (kD predicted)

(Colussi et al., 2000)

325 (aa); 35 (kD predicted)

(Igaki et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Debcl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.16

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 5
organism | ubiquitous
(Igaki et al., 2000)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11
posterior midgut primordium
(Colussi et al., 2000)
mesoderm
(Brachmann et al., 2000)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
trunk visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13
embryonic/larval gut
(Brachmann et al., 2000)
embryonic stage 13 -- 16
embryonic hindgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
third instar larval stage
brain | restricted
(Colussi et al., 2000)
eye-antennal disc | restricted
(Colussi et al., 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Colussi et al., 2000)
embryonic stage 5
organism | ubiquitous
(Colussi et al., 2000)
embryonic stage 11
proctodeum
(Colussi et al., 2000)
embryonic stage 14 -- 16
embryonic/larval midgut
(Colussi et al., 2000)
embryonic head segment | restricted
(Colussi et al., 2000)
third instar larval stage
embryonic/larval salivary gland duct
(Colussi et al., 2000)
adult stage & oogenesis
nurse cell
(Colussi et al., 2000)
oocyte
(Colussi et al., 2000)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Igaki et al., 2000)
third instar larval stage
wing disc
(Igaki et al., 2000)
eye disc
(Igaki et al., 2000)
embryonic/larval midgut
(Igaki et al., 2000)
leg disc
(Igaki et al., 2000)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Brachmann et al., 2000)
adult stage | male
head
(Brachmann et al., 2000)
abdomen & thorax
(Brachmann et al., 2000)
adult stage | female
head
(Brachmann et al., 2000)
abdomen & thorax
(Brachmann et al., 2000)
Additional Descriptive Data

RT-PCR analysis indicates that Debcl transcripts are expressed at all stages of development. In situ hybridization reveals that Debcl transcripts are expressed at high levels in early embryos. Expression is also observed in third instar larvae in leg, wing, and eye disc and in the midgut.

(Igaki et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of Bcl-2 family protein complex
inferred from physical interaction with FLYBASE:synr; FB:FBgn0031650,FLYBASE:Buffy; FB:FBgn0040491
(Ikegawa et al., 2023)
located_in mitochondrial envelope
inferred from direct assay
(Igaki et al., 2000)
located_in mitochondrion
inferred from direct assay
(Doumanis et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Debcl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Debcl
Transgenic constructs containing regulatory region of Debcl
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)hfl-37
(Rendina et al., 2010)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage, with Scer\GAL4da.G32
partially lethal - majority die | larval stage, with Scer\GAL4elav-C155
partially lethal - majority die | pupal stage, with Scer\GAL4elav-C155
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Debcl6)
viable (with Debcl22)
viable (with Debcl23)
viable (with Debcl27)
viable (with Debcl59)
viable (with Debcl61)
viable (with DebclKO-unspecified)
Sterility
Allele
fertile
fertile (with Debcl6)
fertile (with Debcl22)
fertile (with Debcl23)
fertile (with Debcl27)
fertile (with Debcl59)
fertile (with Debcl61)
fertile (with DebclKO-unspecified)
Other Phenotypes
Allele
abnormal locomotor behavior, with Scer\GAL4elav-C155
abnormal locomotor behavior | progressive, with Scer\GAL4Ddc.PL
abnormal neuroanatomy | somatic clone, with Scer\GAL4ppk.1.9
abnormal size | adult stage, with Scer\GAL4GMR.PU
decreased cell death | embryonic stage
decreased cell death | embryonic stage, with Scer\GAL4da.G32
decreased cell death | embryonic stage (with Debcl22)
decreased cell death | embryonic stage (with Debcl27)
decreased cell death | embryonic stage (with Debcl59)
decreased cell death | embryonic stage (with Debcl61)
decreased cell death | spermatogenesis
hyperplasia | adult stage
increased cell death, with Scer\GAL4109-88
increased cell death, with Scer\GAL4ey.PH
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4hs.PB
increased cell death | third instar larval stage, with Scer\GAL4ptc.PU
increased cell number | adult stage, with Scer\GAL4esg.PU
long lived, with Scer\GAL4elav-C155
radiation sensitive
radiation sensitive (with Debcl22)
radiation sensitive (with Debcl27)
radiation sensitive (with Debcl47)
radiation sensitive (with Debcl48)
radiation sensitive (with Debcl59)
radiation sensitive (with Debcl61)
short lived, with Scer\GAL4Ddc.PL
short lived, with Scer\GAL4elav-C155
some die during larval stage, with Scer\GAL4da.G32
visible
visible, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage, with Scer\GAL4ptc.PU
Phenotype manifest in
Allele
abdominal sternite
abdominal tergite
adult gut, with Scer\GAL4esg.PU
anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc.PU
Bolwig organ | embryonic stage
dendrite & abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
dendrite & class IV dendritic arborising neuron, with Scer\GAL4ppk.1.9
dendrite & dorsal multidendritic neuron ddaC | somatic clone, with Scer\GAL4ppk.1.9
eye
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | adult stage, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4ey.PH
eye disc, with Scer\GAL4GMR.PF
eye disc | posterior, with Scer\GAL4GMR.PF
eye photoreceptor cell
genital chamber
interommatidial bristle
larval ventral nerve cord | embryonic stage (with Debcl22)
larval ventral nerve cord | embryonic stage (with Debcl27)
larval ventral nerve cord | embryonic stage (with Debcl59)
larval ventral nerve cord | embryonic stage (with Debcl61)
male genitalia
maxillary palp
melanotic mass
midline glial cell | embryonic stage | increased number
mitochondrion & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
ommatidium
ommatidium | adult stage, with Scer\GAL4GMR.PF
pigment cell
pigment cell, with Scer\GAL4GMR.PF
salivary gland, with Scer\GAL4109-88
scutellar bristle | increased number
spermatogonium
testis | adult stage
wing, with Scer\GAL4en-e16E
wing | adult stage, with Scer\GAL4ptc.PU
wing margin | conditional (with Debcl22)
wing margin | conditional (with Debcl27)
wing margin | conditional (with Debcl47)
wing margin | conditional (with Debcl48)
wing margin | conditional (with Debcl59)
wing margin | conditional (with Debcl61)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (12)
Hsap\BOK
12 of 14
Yes
No
Hsap\BAK1
2 of 14
No
Yes
Hsap\BAX
2 of 14
No
Yes
Hsap\BCL2A1
2 of 14
No
Yes
Hsap\BCL2L1
2 of 14
No
Yes
Hsap\BCL2L2
2 of 14
No
Yes
Hsap\BCL2L10
2 of 14
No
Yes
Hsap\BCL2L14
2 of 14
No
Yes
Hsap\MCL1
2 of 14
No
Yes
Hsap\BCL2
1 of 14
No
Yes
1  
Hsap\BCL2L2-PABPN1
1 of 14
No
No
Hsap\BCL2L13
1 of 14
No
Yes
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Bok
12 of 14
Yes
No
Rnor\Bak1
2 of 14
No
Yes
Rnor\Bax
2 of 14
No
Yes
Rnor\Bcl2a1
2 of 14
No
Yes
Rnor\Bcl2l1
2 of 14
No
Yes
Rnor\Bcl2l2
2 of 14
No
Yes
Rnor\Bcl2l10
2 of 14
No
Yes
Rnor\Bcl2l14
2 of 14
No
Yes
Rnor\Bcl2
2 of 14
No
Yes
Rnor\Bcl2l13
1 of 14
No
Yes
Rnor\Mcl1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (13)
Mmus\Bok
11 of 14
Yes
No
Mmus\Bak1
2 of 14
No
Yes
Mmus\Bax
2 of 14
No
Yes
1  
Mmus\Bcl2a1a
2 of 14
No
Yes
Mmus\Bcl2a1b
2 of 14
No
Yes
Mmus\Bcl2a1c
2 of 14
No
Yes
Mmus\Bcl2a1d
2 of 14
No
Yes
Mmus\Bcl2l1
2 of 14
No
Yes
Mmus\Bcl2l2
2 of 14
No
Yes
Mmus\Bcl2l10
2 of 14
No
Yes
Mmus\Bcl2l14
2 of 14
No
Yes
Mmus\Bcl2
2 of 14
No
Yes
Mmus\Mcl1
2 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\bok
6 of 13
Yes
No
Xtro\bcl2l2
1 of 13
No
Yes
Xtro\bcl2l10
1 of 13
No
Yes
Xtro\bcl2
1 of 13
No
Yes
Xtro\mcl1
1 of 13
No
Yes
Danio rerio (Zebrafish) (14)
Drer\boka
12 of 14
Yes
No
Drer\bokb
12 of 14
Yes
Yes
Drer\baxa
2 of 14
No
Yes
Drer\bcl2b
2 of 14
No
Yes
Drer\bcl2l1
2 of 14
No
Yes
Drer\bcl2l10
2 of 14
No
Yes
Drer\bcl2l16
2 of 14
No
Yes
Drer\LOC100004321
2 of 14
No
Yes
Drer\mcl1a
2 of 14
No
Yes
Drer\mcl1b
2 of 14
No
Yes
Drer\baxb
1 of 14
No
Yes
Drer\bcl2a
1 of 14
No
Yes
Drer\LOC100534669
1 of 14
No
Yes
Drer\zgc:153993
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ced-9
2 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP011552
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Debcl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Buffy
11 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Debcl27
    model of  testicular cancer
    CEA with DroncL32
    (Napoletano et al., 2017)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BOK; BCL2 family apoptosis regulator BOK
    12 of 14
    605404
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Debcl
        suppressible
        Buffy
        (M'Angale and Staveley, 2016, Tsubouchi et al., 2009, Quinn et al., 2003)
        Debcl
        suppressible
        Dark
        (Colussi et al., 2000)
        Debcl
        enhanceable
        Prosα2
        (Colin et al., 2014)
        Debcl
        suppressible
        Rpn10
        (Colin et al., 2014)
        Debcl
        enhanceable
        slmb
        (Colin et al., 2014)
        Debcl
        suppressible
        Uba1
        (Colin et al., 2014)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Ank2
        suppressible
        Debcl
        (Keller et al., 2011)
        Dark
        enhanceable
        Debcl
        (Galindo et al., 2009)
        mad2|bsk
        suppressible
        Debcl
        (Wong et al., 2014)
        synr
        suppressible
        Debcl
        (Sulekh et al., 2024, Ikegawa et al., 2023)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        42B2-42C1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        42B2-42C1
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        42B-42B
        (Zhou, 2000.1.6)
        42E-43A
        (Brachmann, 2000.3.10, Colussi, 1999.8.17, Kurada, 1999.12.14)
        Experimentally Determined Recombination Data
        Location

        2-55

        (FlyBase, 2016)

        2-56.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (16)
        Genomic Clones (22)
        cDNA Clones (30)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

            (Liu and Lehmann, 2008)

            debcl is not essential for normal development.

            (Sevrioukov et al., 2007)

            debcl protects neurons from neurodegeneration through the regulation of mitochondrial homeostasis.

            (Senoo-Matsuda et al., 2005)

            dsRNA made from templates generated with primers directed against this gene causes a phenotype in S2 cells. The reduced mitochondrial membrane potential and increase in cell death caused by treatment of cells with rotenone or 3-NP is enhanced. Cell death induction by treatment with proteasome inhibitors is likewise enhanced, while cell death induction by tunicamycin is not affected. Additionally, debcl knockdown significantly increases the percentage of mitochondria showing abnormal morphologies in S2 cells with intact nuclei and enhances the reduction of activities of mitochondrial respiratory chain complex I +III (NADH-cytochrome c oxidoreductase) and complex II +III (succinate-cytochrome c oxidoreductase) in S2 cells treated with rotenone or 3-NP.

            (Senoo-Matsuda et al., 2005)

            Area matching Drosophila ESTs AI062455 and AA440915.

            (Davies, 2001.3.15)

            debcl both induces apoptosis and demonstrates protective activity when death stimuli are introduced.

            (Brachmann et al., 2000)

            debcl encodes a pro-apoptotic protein that functions in a caspase-dependent manner. debcl is required for developmental apoptosis in the embryo.

            (Colussi et al., 2000)

            debcl appears to promote cell death by inducing both caspase-dependent and independent pathways at the mitochondria.

            (Igaki et al., 2000)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: debcl BOK

            (Bayraktaroglu, 2000.5.24)

            Source for merge of: debcl CG12397

            (FlyBase, 1996-)
            Additional comments

            Source for merge of debcl CG12397 was sequence comparison ( date:000815 ).

            (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: Debcl debcl

            (Steller et al., 2014.7.9)
            Nomenclature comments

            Capitalized initial letter of gene symbol and name to be consistent with similarly named 'death genes' and to follow FlyBase nomenclature rules.

            (Steller et al., 2014.7.9)
            Etymology
            Synonyms and Secondary IDs (46)
            Reported As
            Symbol Synonym
            BCL-2
            (Heron et al., 2023)
            BG1
            (Zhou, 2000.1.6)
            BOK
            (Bayraktaroglu, 2000.5.24)
            BUFFY
            (Tamturk et al., 2025)
            Bak/Bax
            (Qin et al., 2020)
            Bcl 2
            (Rasheed et al., 2023)
            Bcl-2
            (Rost-Roszkowska et al., 2025, Zhang et al., 2015, Keller et al., 2011)
            Bcl2
            (Xu et al., 2018)
            Bok
            (Tittel and Steller, 2000)
            Bok(Debcl)
            (Lanave et al., 2004)
            CG12397
            (Brody et al., 2002, Richardson, 2001.4.10, Brody, 2000.9.6)
            CG33134
            (National Institute of Genetics Fly Stocks, 2022-, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Wagner et al., 2009, Carrera et al., 2008)
            DBok
            (Sevrioukov et al., 2007, Zhang et al., 2000)
            DEBCL
            (Sentürk et al., 2020, Doumanis et al., 2007, Buszczak and Cooley, 2000)
            Dbok
            (Gorski and Marra, 2002, Zhang et al., 2000)
            Debcl
            (Fehr et al., 2025, He et al., 2025, Scopelliti et al., 2025, Serebrovska et al., 2025, Xiu et al., 2025, Yadav et al., 2025, Farodoye et al., 2024, Hasan and Staveley, 2024, Shan et al., 2024, Sulekh et al., 2024, Tang et al., 2024, Umargamwala et al., 2024, Ikegawa et al., 2023, Li et al., 2023, Feng et al., 2022, Periasamy et al., 2022, Yang et al., 2022, Bilder et al., 2021, Buhlman et al., 2021, Hounsell and Fan, 2021, Nakajima et al., 2020, Hall et al., 2019, Meltzer et al., 2019, Wu et al., 2019, Gene Disruption Project members, 2018-, Galluzzi et al., 2017, Kutscher and Shaham, 2017, Transgenic RNAi Project members, 2017-, Dabrowska et al., 2016, M'Angale and Staveley, 2016, Nakazawa et al., 2016, Padash Barmchi et al., 2016, Arya and White, 2015, Denton and Kumar, 2015, Kavi et al., 2015, Sakamaki et al., 2015, Colin et al., 2014, Steller et al., 2014.7.9, Ly et al., 2013, Abdelwahid et al., 2011, Bangi et al., 2011, Kanda et al., 2011, Kuranaga, 2011, Galindo et al., 2009, Shim et al., 2009, Tsubouchi et al., 2009, Copeland et al., 2007, Kuranaga and Miura, 2007, Martin et al., 2007, Kornbluth and White, 2005, Quinn et al., 2003, Gorski and Marra, 2002, Chen and Abrams, 2000, Colussi et al., 2000)
            Debcl/Drob-1/dBorg-1/dBok
            (Danial and Korsmeyer, 2004)
            Debcl/dBorg-1/dBok/Drob-1
            (Galindo and Abrams, 2007)
            Debcl/dBorg-1/dRob-1
            (Richardson and Kumar, 2002)
            Drob-1
            (Nakazawa et al., 2016, Kang and Ryoo, 2009, Sevrioukov et al., 2007, Kornbluth and White, 2005, Senoo-Matsuda et al., 2005, Senoo-Matsuda et al., 2004, Gorski and Marra, 2002, Igaki et al., 2002, Chen and Abrams, 2000, Igaki et al., 2000, Igaki, 1999.9.14)
            Drob-1/Debcl/dBORG-1
            (Baehrecke, 2000)
            Drob-1/Debcl/dBorg-1/DBok
            (Vernooy et al., 2000)
            Drob-1/Debcl/dBorg-1/dBok
            (Igaki and Miura, 2004)
            bcl-2
            (Wong et al., 2014, Brun et al., 2002)
            borg1/debcl
            (Ortega et al., 2005)
            buffy
            (Kuranaga, 2011)
            dBOK
            (Van Hoof and Goris, 2003)
            dBORG-1/DROB-1/DEBCL/dBOK
            (Meier et al., 2000)
            dBok
            (Tsubouchi et al., 2009, Kornbluth and White, 2005)
            dBorg-1
            (Kornbluth and White, 2005, Brachmann and Cagan, 2001, Brachmann et al., 2000, Vernooy et al., 2000)
            dBorg01
            (Gorski and Marra, 2002)
            dBorg1
            (Sevrioukov et al., 2007, Jassim et al., 2001)
            dBrog-1
            (Tsubouchi et al., 2009)
            dbok
            (Vernooy et al., 2000)
            dbok/debcl
            (Brun et al., 2002)
            dborg1
            (Brachmann, 2000.3.10)
            debc1
            (Blanco et al., 2010)
            debcl
            (Frat et al., 2023, Volin et al., 2018, Lindström et al., 2017, Napoletano et al., 2017, Yamaguchi et al., 2017, Kuleesha et al., 2016, Mao et al., 2016, Colin et al., 2014, de la Cova et al., 2014, Ly et al., 2013, Yacobi-Sharon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Bonner and Boulianne, 2011, Grusche et al., 2011, Keller et al., 2011, Luo et al., 2011, Park et al., 2010, Rendina et al., 2010, Terhzaz et al., 2010, Wu et al., 2010, Tsubouchi et al., 2009, Wagner et al., 2009, Carrera et al., 2008, Hou et al., 2008, Liu and Lehmann, 2008, Cao et al., 2007, Monserrate et al., 2007, Peterson et al., 2007, Sevrioukov et al., 2007, Hoskins et al., 2005, Colussi et al., 2000)
            debcl/Borg1
            (Burr et al., 2005, Purves et al., 2005)
            debok
            (Brun et al., 2001)
            drob-1
            (Tsubouchi et al., 2009, Brun et al., 2001, Vernooy et al., 2000)
            Name Synonyms
            Bcl-2
            (Keller et al., 2011)
            Death executioner Bcl-2
            Death executioner Bcl-2 homologue
            (Steller et al., 2014.7.9)
            death executioner Bcl-2 homologue
            (Mukherjee et al., 2020, Colussi et al., 2000)
            death inducing Bcl-2-like protein
            (Colussi et al., 2000)
            deborg
            (Brun et al., 2001)
            Secondary FlyBase IDs
            • FBgn0029509
            • FBgn0033080
            • FBgn0053134
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 63 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (186)